Abstract We recently reported LMAN1 as a regulatory receptor capable of downregulating NF-kB signaling in response to house dust mite (HDM) vitro. In this follow up work, we have subjected WT and KO mice HDM model allergic airway inflammation assessed lung function hyperreactivity (AHR). Given our previous vitro findings, had expected worsened disease the absence LMAN1. Interestingly, when were...

Background Infants with family history of atopy are considered at high risk for developing allergic disease. Environmental exposures are modifiable risk factors with a potential for intervention to prevent allergy. Children who develop house dust mite (HDM) sensitisation by pre-school age are at higher risk of developing asthma. Prevention of HDM sensitisation in early childhood by immune modul...

The homogenization design method (HDM) is extended to obtain an optimal topology of magnetic fields. This is accomplished by maximizing the magnetic mean compliance in a given region of the device. HDM is applied to a three-dimensional case, taking into account the saturation effect of the material. Results show that HDM is valid to maximize the vector potential and the magnetic energy. This me...

We put into exercise a comparatively innovative analytical modus operandi, the homotopy decomposition method (HDM), for solving a system of nonlinear partial differential equations arising in an attractor one-dimensional Keller-Segel dynamics system. Numerical solutions are given and some properties show evidence of biologically practical reliance on the parameter values. The reliability of HDM...

The specific absorption rate (SAR) is an important issue to be considered in fetus MRI at 3 T due to the high radiofrequency energy deposited inside the body of pregnant woman. The high dielectric material (HDM) has shown its potential for enhancing B1 field and reducing SAR in MRI. The aim of this study is to assess the feasibility of SAR reduction by adding an HDM to the fetus MRI. The feasib...

Since tropomyosin is cross reactive in many arthropods, it was assumed that this highly conserved protein could be responsible for cross reactions in house dust mite (HDM) allergic patients who experienced adverse reactions after crustacean and mollusc ingestion. Here we report two clinical cases where the role of tropomyosin is a matter of debate. In the first case, the clinical history, as we...

High-dose melphalan (HDM) plus stem cell transplantation is an effective treatment for light-chain amyloidosis (AL), but is associated with high treatment-related mortality in patients with cardiac involvement. We studied 187 patients with cardiac involvement with AL who underwent HDM between 1996 and 2008. The median age was 57 years and the median time from diagnosis to HDM was 3.6 months. Ha...

Background Skin prick tests (SPTs) has relatively a good correlation with allergen-specific IgE against house dust mites (HDM) and pollens, whereas their correlation to fungi remains low. We aimed to investigate the correlation between results of serum specific IgE and SPTs for HDM or fungi in patients with chronic lower respiratory symptoms. The clinical difference between serum fungus or HDM-...

Abstract Background House dust mite (HDM) inhalation can cause airway epithelial damage which is implicated in the process of inflammation asthma. High mobility group box 1 (HMGB1) critically required for cellular and apoptosis as an important endogenous danger signal. Recently, Clara cell 16KDa protein (CC16) has been identified to exert anti-inflammatory immunomodulatory influence various inj...

The GTPase-accelerating protein, regulator of G-protein signalling 2 (RGS2) reduces signalling from G-protein-coupled receptors (GPCRs) that signal via Gαq. In humans, RGS2 expression is up-regulated by inhaled corticosteroids (ICSs) and long-acting β2-adrenoceptor agonists (LABAs) such that synergy is produced in combination. This may contribute to the superior clinical efficacy of ICS/LABA th...