HCN channels comprise a small subfamily of proteins within the superfamily of pore-loop cation channels. In mammals, the HCN channel family includes four members (HCN1-4) that are expressed in the heart and in the nervous system. Hyperpolarization-activated cation currents produced by HCN channels (Ih, If or Iq), contribute to a wide range of physiological functions including cardiac and neuron...

The global response regulator GacA of Pseudomonas aeruginosa PAO1 positively controls the production of the quorum sensing signal molecule N-butanoyl-homoserine-lactone (C4-HSL) and hence the synthesis of several C4-HSL-dependent virulence factors, including hydrogen cyanide (HCN). This study presents evidence that GacA positively influences the transcription of the rhlI gene, specifying C4-HSL...

Aims of course/workshop Because the urinary bladder can contract voluntarily through myogenic excitation, it would be reasonable to predict that the bladder has the potential for self-excitation. The physiological effects of the hyperpolarization-activated nucleotide-gated (HCN) channel in initiating and modulating bladder excitability need to be investigated. Moreover, the interstitial cells o...

RUST, L. A., W. E. FRY, and S. V. BEER. 1980. Hydrogen cyanide sensitivity in bacterial pathogens of cyanogenic and non-cyanogenic plants. Phytopathology 70:1005-1008. The cyanide sensitivity of bacterial pathogens of cyanogenic and nongenerally were more sensitive to HCN than were the xanthomonads tested. cyanogenic plants was determined by observing the effects of HCN on their Among xanthomon...

An ab initio study of the stability, spectroscopic properties, and isomeric equilibrium of the hydrogen-bonded HCN...H2O and H2O...HCN isomers is presented. Density functional theory and perturbative second-order MP2 and coupled-cluster CCSD(T) calculations were carried out and binding energies obtained with correlation-consistent basis sets including extrapolation to the infinity basis set lev...

Voltage-gated channels are normally opened by depolarization and closed by repolarization of the membrane. Despite sharing significant sequence homology with voltage-gated K(+) channels, the gating of hyperpolarization-activated, cyclic-nucleotide-gated (HCN) pacemaker channels has the opposite dependence on membrane potential: hyperpolarization opens, whereas depolarization closes, these chann...

Numerous electrophysiological studies on branchial K(+) transport in brachyuran crabs have established an important role for potassium channels in osmoregulatory ion uptake and ammonia excretion in the gill epithelium of decapod crustaceans. However, hardly anything is known of the actual nature of these channels in crustaceans. In the present study, the identification of a hyperpolarization-ac...

The physiological dormancy of sunflower (Helianthus annuus) embryos can be overcome during dry storage (after-ripening) or by applying exogenous ethylene or hydrogen cyanide (HCN) during imbibition. The aim of this work was to provide a comprehensive model, based on oxidative signaling by reactive oxygen species (ROS), for explaining the cellular mode of action of HCN in dormancy alleviation. B...

A four-dimensional intermolecular potential-energy surface has been calculated for the HCN-HCl complex, with the use of the coupled cluster method with single and double excitations and noniterative inclusion of triples. Data for more than 13,000 geometries were represented by an angular expansion in terms of coupled spherical harmonics; the dependence of the expansion coefficients on the inter...

Person re-identification (person re-ID) aims at matching target person(s) grabbed from different and non-overlapping camera views. It plays an important role for public safety and has application in various tasks such as, human retrieval, human tracking, and activity analysis. In this paper, we propose a new network architecture called Hierarchical Cross Network (HCN) to perform person re-ID. I...