Rats were weaned onto high (HCa, 14.6 g/kg)- or low (LCa, 3.88 g/kg)-Ca diets for 12 d and the efficiency of absorption of Ca measured from 20 mg Ca (as CaCl2, labelled with 47Ca) by means of whole-body counting. The LCa group absorbed 74% of the test dose and the HCa group 60% of the test dose (P < 0.001). All animals were then given the LCa diet for 6 weeks and the absorption test repeated. T...

Elementary cellular automaton (ECA) rules 9 and 74, members of Chua’s Bernoulli shift rules and Wolfram’s class 2, can generate a host of gliders and complicated glider collisions by introducing the hybrid mechanism. These gliders and collisions are more plentiful than those generated by ECA rule 110. This paper presents a discussion of the symbolic dynamics of the gliders in hybrid cellular au...

Selective inhibition of tumor-associated carbonic anhydrase (CA; EC 4.2.1.1) isoforms IX and XII is a crucial prerequisite to develop successful anticancer therapeutics. Herein, we confirmed the efficacy of the 3-nitrobenzoic acid substructure in the design of potent and selective carboxylic acid derivatives as CAs inhibitors. Compound 10 emerged as the most potent inhibitor of the tumor-associ...

Silica nanoparticle supported imidazolium ionic liquid [SNImIL] was synthesized and utilized as a biocompatible additive for studying the thermal reversibility of human carbonic anhydrase II (HCA II). For this purpose, we prepared additive by modification of nanoparticles through the grafting of ionic liquids on the surface of nanoparticles (SNImIL). The SNImIL were fully characterized by Fouri...

OBJECTIVES This study was designed to evaluate the surgical treatment of recurrent coarctation by a new technique. BACKGROUND Recurrent coarctation either from aneurysm or recurrent constriction is a difficult problem in the adult because of the possible interruption of important collateral circulation. METHODS We reviewed four patients who underwent recurrent coarctation surgery with the u...

Cholinium-based ionic liquids (Cho-ILs) are very attractive compounds for medicinal and pharmaceutical applications as bioavailability enhancers in drug formulations active components ingredients. In this study, we synthesized six Cho-ILs from hydroxycinnamic acids (HCA) ([Cho][HCA] ILs), a group of bioactive with poor water solubility. [Cho][HCA] ILs their parent were evaluated solubility, the...

Background and objectives: Attenuated total reflectance-inferared (ATR-IR) spectra can be used as a non-invasive fingerprinting approach in quality control of herbal samples. Methods: Twenty versatile herbal samples were subjected to attenuated total reflectance-inferared (ATR-IR) spectroscopy followed by different clustering methods in order to determine by which method more reasonable classif...

Background/Aims: There are several imaging modalities available for the detection of focal liver lesions. Differentiation between focal nodular hyperplasia (FNH) and hepatocellular adenoma (HCA) is important because of the consequences for management. However, differentiation based on imaging alone still shows limitations. Methods: We reviewed the literature for typical features of FNH and HCA ...

Spontaneous preterm birth is often caused by chorioamnionitis. Toll-like receptors (TLRs) have a role in the response of the innate immune system. The role of TLR5 in chorioamnionitis remains unclear: however, TLR5 was reported to have a significantly stronger effect on the induction of interleukin (IL)-6 when compared with other TLRs in amniotic epithelial cells. The aim of this study was to i...

To find a disulfide pair that could stabilize the enzyme human carbonic anhydrase II (HCA II), we grafted the disulfide bridge from the related and unusually stable carbonic anhydrase form from Neisseria gonorrhoeae (NGCA) into the human enzyme. Thus, the two Cys residues at positions 23 and 203 were engineered into a pseudo-wild-type form of HCA II (C206S), giving the mutant C206S/A23C/L203C. ...