The homeodomain transcription factor Crx is required for expression of many photoreceptor genes in the mammalian retina. The mechanism by which Crx activates transcription remains to be determined. Using protein-protein interaction assays, Crx was found to interact with three co-activator proteins (complexes): STAGA, Cbp and p300, all of which possess histone acetyl-transferase (HAT) activity. ...

Physiological measurements of nitrate (NO(3)(-)) uptake by roots have defined two systems of high and low affinity uptake. In Arabidopsis, genes encoding both of these two uptake systems have been identified. Most is known about the high affinity transport system (HATS) and its regulation and yet measurements of soil NO(3)(-) show that it is more often available in the low affinity range above ...

Histone acetyltransferases (HATs) GCN5 and PCAF (GCN5/PCAF) and CBP and p300 (CBP/p300) are transcription co-activators. However, how these two distinct families of HATs regulate gene activation remains unclear. Here, we show deletion of GCN5/PCAF in cells specifically and dramatically reduces acetylation on histone H3K9 (H3K9ac) while deletion of CBP/p300 specifically and dramatically reduces ...

Esophageal carcinoma (EC) is one of the most fatal carcinomas of the gastrointestinal tract. Aberrant activity of histone acetyltransferases (HATs)/deacetylases (HDACs) play a critical role in carcinogenesis through the regulation of the genes involved in cell differentiation, proliferation, and apoptosis. However, cellular functions of HATs/HDACs in esophageal cancer and its molecular mechanis...

Histone acetylation at DNA double-strand break (DSB) sites by CBP and p300 histone acetyltransferases (HATs) is critical for the recruitment of DSB repair proteins to chromatin. Here, we show that CBP and p300 HATs also function in DSB repair by transcriptionally activating the BRCA1 and RAD51 genes, which are involved in homologous recombination (HR), a major DSB repair system. siRNA-mediated ...

Overcoming the intrinsic instability and preserving unique electronic properties are key challenges for practical applications of black phosphorus (BP) under ambient conditions. Here, it is demonstrated that molecular heterostructures BP hexaazatriphenylene derivatives (BP/HATs) enable improved environmental stability charge transport properties. The strong interfacial coupling transfer between...

The headphone transfer function (HpTF) is a major source of spectral coloration observable in binaural synthesis. Filters for frequency response compensation can be derived from measured HpTFs. Therefore, we developed a method for measuring HpTFs reliably at the blocked ear canal. Subsequently, we compared non-individual dynamic binaural simulations based on recordings from a head and torso sim...

We study the role of sizes of neural networks (NNs) in TRAP (TempoRAl Patterns) and HATS (Hidden Activation TRAPS architecture) probabilistic features extraction. The question of sufficient size of band NNs is linked with the question whether the Merger is able to compensate for lower accuracy of band NNs. For both architectures, the performance increases with increasing size of Merger NN. For ...