The aim of this work was to study the effect a high fat and carbohydrate diet (HFCD) quercetin supplementation on levels dopamine (DA), serotonin (5-HT) their metabolites in Wistar, DA transporter knockout (DAT-KO) obese Zucker fa/fa rats. Animals received control or HFCD for 62 days. Wistar rats quercetin. contents DA, 5-HT, norepinephrine (NE), dioxyphenyl acetate (DOPAC), homovanillic acid (...

Photonic integrated circuits have been designed, simulated, and tested on TriPleX™ platform technology for implementing optical Haar Transform (HT) in the visible spectrum. Optical contain new building block (BB), designed using multimode interference (MMI) structure, performing HT a pair of signals. The Outputs BB demonstrate sum subtraction input signals according to operation. 1st-order 2nd-...

OBJECTIVE We sought to understand the relationship among components of residency education about hormone therapy (HT), knowledge about HT, and provider attitudes toward HT during a time of rapidly changing practice guidelines. METHODS We surveyed residents in the University of Pittsburgh Internal Medicine residency programs between February to April 2002 (after the release of the Heart Estrog...

Serotonin (5-hydroxytryptamine, 5-HT) modulates the behavior and physiology of both vertebrate and invertebrate animals. Effects of injections of 5-HT and the morphology of the serotonergic system of Aplysia indicate that 5-HT may have a humoral, in addition to a neurotransmitter, role. To study possible humoral roles of 5-HT, we measured 5-HT in the hemolymph. The concentration of 5-HT in the ...

Ion mobility spectrometry (IMS) has been widely used for the on-site detection of trace chemicals, but continue to suffer from a low duty cycle ion injection. The Hadamard transform (HT-IMS) technique was employed address problem with increased signal-to-noise ratio (SNR). However, in this work, through simulation, certain deviation between mathematical principle and actual data collection proc...

Homomeric 5-hydroxytryptamine (5-HT)(3A) and heteromeric 5-HT(3AB) receptors mediate rapid excitatory responses to serotonin in the central and peripheral nervous systems. The alkaloid morphine, in addition to being a mu-opioid receptor agonist, is a potent competitive inhibitor of 5-HT(3) receptors. We examined whether methadone, an opioid often used to treat morphine dependence, also exhibite...

Previous studies have established a role for 5-hydroxytryptamine (5-HT)(2B) and 5-HT(1B) receptors in mediating enhanced contraction to serotonin (5-HT) in arteries from hypertensive deoxycorticosterone acetate (DOCA)-salt rats. To determine whether the observed increase in responsiveness was due to upregulation of 5-HT receptors, we used Western analysis to measure 5-HT(1B) and 5-HT(2B) recept...

It is well established that serotonin (5-HT; 5-hydroxytryptamine) plays a role in mammalian regulation of the hypothalamic-pituitary-adrenal (HPA) axis via the 5-HT receptor subtype 1A (5-HT(1A)). To date, there has not been a comprehensive investigation of the molecular, pharmacological and physiological aspects of the 5-HT(1A) receptor and its role in the activation of the hypothalamic-pituit...

Serotonin 5-HT 2C receptors belong to the 5-HT 2 family, which includes 5-HT 2A and 5-HT 2B receptors. All three share similarities in their molecular structure, pharmacology, and signal transduction pathways (Barnes and Sharp 1999; Hoyer et al. 1994). Initially named 5-HT 1C, based on the conventions for naming serotonin receptors at the time of its discovery, it was later renamed 5-HT 2C rece...

We previously demonstrated colocalization of serotonin 1A (5-HT(1A)) and serotonin 2A (5-HT(2A)) receptors in oxytocin and corticotropin-releasing factor neurons in the hypothalamic paraventricular nucleus (PVN). Because a functional imbalance between hypothalamic 5-HT(1A) and 5-HT(2A) receptors has been implicated in several neuropsychiatric disorders, in this study we investigated whether acu...