نتایج جستجو برای: hamp 6 pichpyzdh2o
تعداد نتایج: 956869 فیلتر نتایج به سال:
BACKGROUND Expression of the key iron regulatory hormone hepcidin is increased by some stimuli (iron loading, inflammation) but decreased by others (increased erythropoiesis, iron deficiency). We investigated the response of hepcidin to increased erythropoiesis and iron deficiency in the presence of an acute inflammation to assess the relative strengths of these stimuli. DESIGN AND METHODS Sp...
The inhibitory environment of the spinal cord and the intrinsic properties of neurons prevent regeneration of axons following CNS injury. However, both ascending and descending axons of the injured spinal cord have been shown to regenerate into grafts of embryonic neural progenitor cells (NPCs). Previous studies have shown that grafts composed of glial-restricted progenitors (GRPs) and neural-r...
BACKGROUND Obesity has been reported to be associated with iron deficiency. However, few studies have investigated iron status in low adiposity. To investigate whether body adiposity was associated with altered hepatic iron status, we compared liver iron levels and markers involved in inflammation and iron absorption in obese, control, and mildly calorie restricted mice. METHODS Seven week ol...
Medical Research Council, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom; College of Medicine, Swansea University, Swansea, United Kingdom; University College of London Cancer Institute, Department of Haematology, University College London, United Kingdom; University of Kelaniya, Colombo, Sri Lanka; National Thalassaemia Centre, District Hospital, Kurun...
Mechanisms that favor Hepatitis C virus (HCV) persistence over clearance are unclear, but involve defective innate immunity. Chronic infection is characterized by hepatic iron overload, hyperferraemia and hyperferittinaemia. Hepcidin modulates iron egress via ferroportin and its storage in ferritin. Chronic HCV patients have decreased hepcidin, while HCV replication is modified by HAMP silencin...
BACKGROUND Anemia is very common in patients with human immunodeficiency virus (HIV)-associated tuberculosis, and hepcidin may be key in mediating this. We explored the relationship between blood hepcidin concentrations and anemia severity, mycobacterial burden and mortality in patients with HIV-associated tuberculosis. METHODS Consecutive unselected HIV-infected adults in South Africa were s...
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