Haliclona tubifera, marine sponge species abundant in Brazilian coastline, presents only a few papers published in the literature. Recently, we have reported the isolation of two modified C18 sphingoid bases: (2R,3R,6R,7Z)-2-aminooctadec-7-ene-1,3, 6-triol and and (2R,3R,6R)-2-aminooctadec-1,3,6-triol. In order to continue our research, in this work aimed at the biological investigation of frac...

We previously reported that extracts of an Indonesian marine sponge Haliclona sp. showed potent cytotoxicity and the induction of apoptosis against human solid cancer cell lines. In this study, we examine the cytotoxic mechanism of the major chemical compound, papuamine, on MCF-7 human breast cancer cells. Papuamine at 5 µM did not show significant cytotoxic effects after incubation for 24 h, b...

The frequency of marine sponges that harbour photosynthetic organisms was examined in a tropical area of the Western Indian Ocean. Out of 77 species from five different habitats in Zanzibar, 55 (71.5%) were found to have photosynthetic activity, as assayed by in situ pulse amplitude modulated (PAM) fluorometry (and validated by measurements of chlorophyll content). A significantly higher percen...

The taxonomic status of a marine actinomycete isolated from the sponge Haliclona sp. collected from Cebu, Philippines, was established using both phenotypic and genotypic data. Strain SPE 10-1(T) exhibited chemotaxonomic and morphological characteristics that were consistent with those of members of the genus Saccharopolyspora. It showed a strict requirement for salt and is the first obligate m...

Abstract: This extensive review covers research published between 2010 and 2012 regarding new compounds derived from marine sponges, including 62 species from 60 genera belonging to 33 families and 13 orders of the Demospongia class (Porifera). The emphasis is on the cytotoxic activity that bioactive metabolites from sponges may have on cancer cell lines. At least 197 novel chemical structures ...

Cryptic species are widespread across the phylum Porifera making the identification of non-indigenous species difficult, an issue not easily resolved by the use of morphological characteristics. The widespread order Haplosclerida is a prime example due to limited and plastic morphological features. Here, we study the reported introduction of Haliclona (Soestella) caerulea from the Caribbean to ...

Sponge samples were taken by SCUBA diving from sixteen sites on the north coast of South Georgia island, south west Southern Ocean. Fifteen new species are described: Iophon husvikensis sp. nov., Clathria (Clathria) stromnessa sp. nov., Clathria (Axosuberites) rosita sp. nov., Clathria (Microciona) matthewsi sp. nov., Lissodendoryx (Ectyodoryx) collinsi sp. nov., Hymedesmia (Hymedesmia) barnesi...

Multidrug resistance has appeared to mitigate the efficiency of anticancer drugs and the possibility of successful cancer chemotherapy. The Hedgehog receptor Patched is a multidrug transporter expressed in several cancers and as such it represents a new target to circumvent chemotherapy resistance. We report herein that paniceins and especially panicein A hydroquinone, natural meroterpenoids pr...

STT-MRAM is one of the most promising non-volatile memory technologies with the potential of becoming a universal memory. However, because of its area, power and latency limitations, STT-MRAM is facing critical bottlenecks in substituting DRAM for main memory. Compared to modern DRAM technology, STT-MRAMs cell area and write power consumption are about four times larger and higher, respectively...