نتایج جستجو برای: hair follicular tumor
تعداد نتایج: 483384 فیلتر نتایج به سال:
Immunosuppressive therapies using calcineurin inhibitors, such as cyclosporine A, are associated with a higher incidence of squamous cell carcinoma formation in mice and humans. Calcineurin is believed to suppress tumorigenesis in part through Nfatc1, a transcription factor expressed primarily in hair follicle bulge stem cells in mice. However, mice overexpressing a constitutively active Nfatc1...
Mycosis fungoides is the most common form of cutaneous T-cell lymphoma, and it rarely exhibits predilection for hair follicle and eccrine gland infiltration. Here, we present 2 similar cases that display folliculotropism with varying amounts of follicular mucinosis, with and without syringotropism. The features observed in both cases were cystic, comedo-like, acneiform lesions; generalized invo...
BACKGROUND Diffuse alopecia areata or canities subita is a rare variant of alopecia in which hair loss is associated with regrowth of white hairs and possible lightening of the skin. Preferential loss of pigmented hair in this disorder may be related to the melanin pigment system and/or melanocytes. Acquired generalized anhidrosis can be associated with autoimmune disease, cancer, graft-vs-host...
The regeneration of the skin and its appendages is thought to occur by the regulated activation of a dedicated stem cell population. A population of cells in the bulge region of the hair follicle has been identified as the putative stem cell of both the follicle and the interfollicular epidermis. While this assertion is supported by a variety of surrogate assays, there has been no direct confir...
The hair remains an integral part of beauty since centuries in most of the cultures. And loss of hair causes a huge negative psychological impact. Thus, people have been trying to find out one or the other treatment to get rid of the baldness. They have tried a variety of treatments ranging from local application of medicines to shampoos and oral medications but none have been able to give a he...
Inverted follicular keratosis is a benign tumor of the skin that is believed to arise from the infundibular portion of the hair follicle above the level of entrance of the sebaceous duct. It was described originally by Helwig in 1954 and since then a number of case reports have been reported in the dermatology and pathology literature. A 55-year-old woman was referred for evaluation of a kerato...
Onset of type I keratin 17 (K17) synthesis marks the adoption of an appendageal fate within embryonic ectoderm, and its expression persists in specific cell types within mature hair, glands, and nail. We report that K17 null mice develop severe alopecia during the first week postbirth, correlating with hair fragility, alterations in follicular histology, and apoptosis in matrix cells. These alt...
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