Although several studies have reported seroprevalences of antibody against avian influenza A(H7N9) virus among poultry workers in southern China, results have varied and data in northern China are scarce. To understand risks of H7N9 and H5N1 virus infections in northern China, a serological cohort study was conducted. Poultry workers, swine workers and the general population in Beijing, China, ...

BACKGROUND An effective vaccine is urgently needed against the H7N9 avian influenza virus. We evaluated the immunogenicity and protective efficacy of a split-virion H7N9 vaccine with or without the oil-in-water adjuvants in ferrets. METHODS Ferrets were vaccinated with 2 doses of unadjuvanted, MF59 or AS03-adjuvanted A/Shanghai/2/2013 (H7N9) vaccine, and the induction of antibodies to hemaggl...

Avian influenza A(H7N9) virus re-emerged in China in December 2013, after a decrease in the number of new cases during the preceding six months. Reassortment between influenza A(H7N9) and local H9N2 strains has spread from China's south-east coast to other regions. Three new reassortments of A(H7N9) virus were identified by phylogenetic analysis: between A(H7N9) and Zhejiang-derived strains, Gu...

BACKGROUND Avian H7N9 virus emerged in China in February 2013 and has since spread widely among China's poultry, causing numerous human infections. OBJECTIVES To compare World Health Organization (WHO) and US commercial influenza assays in detecting avian H7N9 virus in poultry cloacal specimens. STUDY DESIGN Between April 6 and July 15, 2013, 261 cloacal swabs were collected from commercial...

The emerging of new H7N9 influenza virus infection in February 2013 brings attention of world health scientists on its possibility to cause worldwide pandemic. The new H7N9 bird flu is a new disease manifesting with acute respiratory features plus additional atypical clinical manifestations. Of those atypical clinical features, neurological presentation is an interesting issue. This work presen...

OBJECTIVE The present study aimed to analyze clinical features and factors associated with treatment outcomes of H7N9 influenza A virus infection. METHODS The clinical progress in 18 H7N9-infected patients was monitored and recorded. The clinical features of H7N9 infection were noted and factors associated with treatment outcomes were analyzed by univariate analyses. RESULTS The average age...

Emerging Infectious Diseases • www.cdc.gov/eid • Vol. 20, No. 11, November 2014 1955 virus infections in Hangzhou (online Technical Appendix Figure). Prompt control of A(H7N9) infection outbreaks and vaccination against seasonal influenza viruses could reduce the potential for co-infections with A(H7N9) virus and seasonal viruses. Taken together with the previous finding of human co-infection w...

Influenza H7N9 virus infection causes an acute, highly contagious respiratory illness that triggers cell death of infected cells and airway epithelial destruction. RIP3 is a key regulator of cell death responses to a growing number of viral and microbial agents. This study aimed to investigate the role of RIP3 in inflammation of influenza H7N9 virus infection. Here, RIP3 knock out (RIP3-/-) mic...

BACKGROUND On 31 March 2013, the first human infections with the novel influenza A/H7N9 virus were reported in Eastern China. The outbreak expanded rapidly in geographic scope and size, with a total of 132 laboratory-confirmed cases reported by 3 June 2013, in 10 Chinese provinces and Taiwan. The incidence of A/H7N9 cases has stalled in recent weeks, presumably as a consequence of live bird mar...

This document describes options for mitigating human exposure to the avian influenza A(H7N9) virus via birds and their by-products, and options for mitigating the spread of H7N9 in birds. It applies both to countries where H7N9 exists and to those that have not yet identified the virus. It should be read in conjunction with FAO’s current H7N9 risk assessment and surveillance guidelines and will...