This study aimed to investigate the correlation between the expression of CD24 and B7-H3 in breast cancer tissues and the clinical significance. Expression of CD24 and B7-H3 in breast cancer and adjacent tissues were detected by immunohistochemistry. Quantitative PCR was used to detect the expression of CD24 and B7-H3 mRNA in breast cancer and adjacent tissues. The expression of CD24 and B7-H3 ...

The arginine-rich histone, H3, isolated from avian erythrocytes, can dimerize by forming a disulfide linkage between the single cysteine sulfhydryl residues at position 110 of the H3 polypeptide chain. The H3 dimer can be substituted for undimerized H3 in experiments in which the nucleosome is reconstituted from DNA and mixtures of the four "core" histones, H2A, H2B, H3, and H4. We report here ...

Background Peanut allergy has not been well characterized in Italy. Objective Our aim was to better define the clinical features of peanut Italy and detect proteins involved allergic reactions. Methods A total 22 centers participated a prospective survey over 6-month period. Clinical histories were confirmed by in vivo and/or in vitro diagnostic means al...

Background: The Continuous Glucose Monitoring in Women with Type 1 Diabetes Pregnancy Trial (CONCEPTT) found improved health outcomes for mothers and their infants among those randomized to self-monitoring of blood glucose (SMBG) continuous monitoring (CGM) compared SMBG alone. In this study, we evaluated whether CGM or standard was more less costly from the perspective a third-party p...

AbstractStatement of problem Malpositioning implants is one the main factors leading to hard- and soft-tissue deficiencies. Whether static computer-guided implant placement increases accuracy prevents malpositioning unclear. Purpose The purpose this in vitro study was determine defined by trueness precision (according International Organization for Standardization 572...

Background Patients with primary antibody deficiency (PAD) are at increased risk of respiratory tract infections, but our understanding their nature and consequences remains limited. Objective To define the symptomatic microbial burden upper airway infection in adults PAD relative to age-matched controls. Methods Prospective 12-month observational study consisting a d...

To analyze the mechanism by which histone H3 phosphorylation occurs specifically during mitosis, the effect of H1 on mitosis-specific H3 phosphorylation (Ser-10) was investigated in nucleosomes. H1 interaction with H1-depleted nucleosomes suppressed H3 phosphorylation including Ser-10 by approximately 50%. However, H1 interaction with DNA-free histone octamers failed to suppress H3 phosphorylat...

T cell activation is regulated by the innate immune system through positive and negative costimulatory molecules. B7-H3 is a novel B7-like molecule with a putative receptor on activated T cells. Human B7-H3 was first described as a positive costimulator, most potently inducing IFN-gamma production and cellular immunity. In this study we examined the expression and function of mouse B7-H3. B7-H3...

SummaryBacground & aim Pinolenic acid, a major component (~20%) of pine nut oil, is dual agonist the free fatty acid receptors, FFA1 and FFA4, which may regulate release incretins ghrelin from gut. Here, we investigated acute effects hydrolyzed oil (PNO-FFA), delivered to small intestine by delayed-release capsules, on glucose tolerance, insulin, incretin secretion, appetite. ...

Background Coronary Artery Disease-Reporting and Data System (CAD-RADS) standardises Computed Tomography Angiography (CTCA) reporting. calcification can overestimate stenosis. We hypothesized where CAD-RADS category is assigned due to predominantly calcified maximal stenosis (Ca+), the CTCA-derived Fractional Flow Reserve (FFRCT) would be lower compared non-calcified stenoses (Ca-) of ...