Duza, Tasmia, and Ingrid H. Sarelius. Conducted dilations initiated by purines in arterioles are endothelium dependent and require endothelial Ca2 . Am J Physiol Heart Circ Physiol 285: H26–H37, 2003. First published March 13, 2003; 10.1152/ajpheart.00788.2002.—The signaling pathways underlying the regulation of vascular resistance by purines in intact microvessels and particularly in communica...

BACKGROUND Schizophrenia is a major disorder with complex genetic mechanisms. Earlier, population genetic studies revealed the occurrence of strong positive selection in the GABRB2 gene encoding the beta(2) subunit of GABA(A) receptors, within a segment of 3,551 bp harboring twenty-nine single nucleotide polymorphisms (SNPs) and containing schizophrenia-associated SNPs and haplotypes. METHODO...

Although glycerol is the primary carbon source available to halophilic heterotrophic communities, little is known regarding haloarchaeal glycerol metabolism. In this study, a gene encoding a glycerol kinase homolog (glpK; HVO_1541) was deleted from the genome of the haloarchaeon Haloferax volcanii by a markerless knockout strategy. The glpK mutant, KS4, readily grew on yeast extract-peptone com...

Escherichia coli (E.coli) O157 that do not produce Shiga toxin and do not possess flagellar antigen H7 are of diverse H serotypes. In this study, the antibiotic resistance properties, genotype of a set of virulence associated genes and the phylogenetic background of E. coli O157:non-H7 groups were compared. Whole genome sequencing was performed on fourteen O157:non-H7 isolates collected in the ...

The seniority of employees’ claims in the liquidation of insolvent firms, and their rights in the renegotiation of their debt varies greatly across countries. Using a simple model of strategic leverage, we show that the balance between these rights of employees and those of other creditors affects the strategic value of debt: in equilibrium, stronger employees’ seniority rights in bankruptcy li...

Pigs are important reservoirs of Shiga toxin-producing Escherichia coli (STEC). The entrance of these strains into the food chain implies a risk to consumers because of the severity of hemolytic uremic syndrome. This study reports the prevalence and characterization of STEC throughout the pork production chain. From 764 samples, 31 (4.05%) were stx positive by PCR screening. At farms, 2.86% of ...

It is widely recognized that entrepreneurial activity plays an important role in promoting new product innovation, discovering new markets, and replacing inefficient incumbents in a process called “creative destruction”, all of which enhance economic growth. Given the importance of entrepreneurship and small business enterprises it is not surprising that policy makers worldwide (and especially ...

Aspartyl-tRNA synthetase (AspRS) occurs in two types: the discriminating enzyme (D-AspRS) forms only Asp-tRNA(Asp), whereas the nondiscriminating enzyme (ND-AspRS) also synthesizes Asp-tRNA(Asn), which is a required intermediate for protein synthesis in many organisms. We attempted to expand the tRNA recognition of the discriminating Thermococcus kodakaraensis AspRS to that of a ND-AspRS by in ...

Rhesus monkey rhadinovirus (RRV) is a γ-herpesvirus that is closely related tohuman Kaposi sarcoma-associated herpesvirus (KSHV/HHV-8). RRV is the closest relativeto KSHV that has a fully sequenced genome and serves as an in vitro and an in vivo modelsystem for KSHV. The latency-associated nuclear antigen (LANA) protein of both KSHVand RRV plays key roles in the establishment an...

Purpose Technology acceptance research in the L&T contexts has a necessity for enabling significant inclusion of technology educational settings (Scherer et al. , 2019). Despite propensity information communication and to enhance teaching learning process, or rejection is essential. Technological model (TAM) evolved become key depict predictors human behaviour towards prospective (Granic Ma...