In 1997, Patil and co-workers reported the isolation of batzelladines F-I from a red Jamaican sponge incorrectly identified at the time as Batzella sp.1,2 These alkaloids each contain two tricyclic guanidines and were found to induce dissociation of protein tyrosine kinase p56lck from CD4. It was postulated that disruption of this interaction could be used to treat autoimmune disorders. Our int...
