نتایج جستجو برای: gsi index
تعداد نتایج: 398205 فیلتر نتایج به سال:
Drug resistance remains a critical problem in the treatment of patients with multiple myeloma. Recent studies have determined that Notch signaling plays a major role in bone marrow (BM) stroma-mediated protection of myeloma cells from de novo drug-induced apoptosis. Here, we investigated whether pharmacologic inhibition of Notch signaling could affect the viability of myeloma cells and their se...
Life history plasticity can be a strong predictor of the establishment and invasion success introduced fishes. Here, life-history traits four P. parva populations in adjacent ponds Southern England were measured throughout 2013 to determine timing length their reproductive season extent trait plasticity. The relative abundance (as catch per unit effort) was similar, with low variability relatin...
Investigating the physiological potential of seeds and genetic divergence between families is essential to identify promising materials for generation improved populations. This study was undertaken examine germination estimate Passiflora full-sib (FSFs) based on physical seed traits. The experiment consisted 86 FSFs from first cycle recurrent selection resistance cowpea aphid-borne mosaic viru...
The accurate prediction of coal structure is important to guide the exploration and development reservoirs. Most models are interpreted for a single sensitive seam, selection parameters correlated with structure, but they ignore interactions between different attributes. Part it introduces concept geological strength index (GSI) rocks in order achieve multi-element macroscopic description quant...
PURPOSE Accumulating evidence supports the existence of breast cancer stem cells (BCSC), which are characterized by their capacity to self-renew and divide indefinitely and resistance to conventional therapies. The Notch pathway is important for stem cell renewal and is a potential target for BCSC-directed therapy. EXPERIMENTAL DESIGN Using human breast tumorgraft studies, we evaluated the im...
OBJECTIVE To validate optical coherence tomography (OCT) imaging for assessment of vascular healing in a preclinical animal model and human autopsy cases and to translate the findings to the assessment of vascular healing after drug-eluting stent implantation in clinical practice. APPROACH AND RESULTS Drug-eluting and bare metal stents were imaged 28 and 42 days after implantation in atherosc...
Constitutive activation of Notch signaling is required for the proliferation of a subgroup of human T-cell acute lymphoblastic leukemias (T-ALL). Previous in vitro studies have demonstrated the therapeutic potential of Notch signaling inhibitors for treating T-ALL. To further examine this possibility, we applied a gamma-secretase inhibitor (GSI) to T-ALL xenograft models. Treatment of establish...
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