OBJECTIVES To prospectively characterize and compare daytime symptoms in primary insomnia (PI) and good sleeper control (GSC) subjects using ecological momentary assessment; to examine relationships between daytime symptom factors, retrospective psychological and sleep reports, and concurrent sleep diary reports. METHODS Subjects included 47 PI and 18 GSC. Retrospective self-reports of daytim...

In this research, another version of the star cube called the generalized-star cube, GSC(n, k,m), is presented as a three level interconnection topology. GSC(n, k,m) is a product graph of the (n, k)-star graph and the m-dimensional hypercube (m-cube). It can be constructed in one of two ways: to replace each node in an m-cube with an (n, k)-star graph, or to replace each node in an (n, k)-star ...

Glioblastoma (GBM) contains stem-like cells (GSCs) known to be resistant to ionizing radiation and thus responsible for therapeutic failure and rapidly lethal tumor recurrence. It is known that GSC radioresistance relies on efficient activation of the DNA damage response, but the mechanisms linking this response with the stem status are still unclear. Here, we show that the MET receptor kinase,...

Modern distributed systems often achieve availability and scalability by providing consistency guarantees about the data they manage weaker than linearizability. We consider a class of such consistency models that, despite this weakening, guarantee that clients eventually agree on a global sequence of operations, while seeing a subsequence of this final sequence at any given point of time. Exam...

Named-Entity Recognition is commonly used to identify biological entities such as proteins, genes, and chemical compounds found in scientific articles. The Human Phenotype Ontology (HPO) is an ontology that provides a standardized vocabulary for phenotypic abnormalities found in human diseases. This article presents the Identifying Human Phenotypes (IHP) system, tuned to recognize HPO entities ...

Stem cell division is tightly controlled via secreted signaling factors and cell adhesion molecules provided from local niche structures. Molecular mechanisms by which each niche component regulates stem cell behaviors remain to be elucidated. Here we show that heparan sulfate (HS), a class of glycosaminoglycan chains, regulates the number and asymmetric division of germline stem cells (GSCs) i...

Low complexity realizations of Least Mean Squared (LMS) error, Generalized Sidelobe Cancellers (GSCs) applied to adaptive beamforming are considered. The GSC method provides a simple way for implementing adaptive Linear Constraint Minimum Variance (LCMV) beamformers. Low complexity realizations of adaptive GSCs are of great importance for the design of high sampling rate, and/or small size and ...

Glioblastoma (World Health Organization/WHO grade IV) is the most common and most aggressive adult glial tumor. Patients with glioblastoma, despite being treated with gross total resection and post-operative radiation/chemotherapy, will almost always develop tumor recurrence. Glioblastoma stem cells (GSC), a minor subpopulation within the tumor mass, have been recently characterized as tumor-in...

Smart antenna technology is a promising means to overcome signal impairments in wireless personal communications. When spatial signal processing achieved through smart antennas is combined with temporal signal processing, the space-time processing can mitigate interference and multipath to yield higher network capacity, coverage, and quality. In this dissertation, we propose a dual smart antenn...

This study contributes to the literature on supply chain coordination by coordinating the research and development (R&D) effort, retail price, and inventory decisions. It investigates a real case in the home appliance industry. The main purpose of this study is to examine the optimal values of R&D effort, pricing, and inventory decisions under decentralized and centralized structures. Then, a d...