The antagonistic pleiotropy (AP) theory posits that aging occurs because alleles that are detrimental in older organisms are beneficial to growth early in life and thus are maintained in populations. Although genes of the insulin signaling pathway likely participate in AP, the insulin-regulated cellular correlates of AP have not been identified. The mitochondrial quality control process called ...

The effects of the reaction terms, diffusion coefficients and size of the computational domain on the dynamics of the two-equation Oregonator model in two-dimensional reactive–diffusive media is studied numerically, and it is shown that spiral waves are robust under truncation or expansion of the computational domain. It is also shown that large diffusion coefficients for the inhibitor may resu...

The effect of the beta-lactam antibiotic cephalexin on the spiral conformation of cells of Aquaspirillum spp. was examined by scanning electron microscopy. A. itersonii and A. peregrinum, which are known to have a left-handed spiral shape, elongated and still showed left-handed spirals in medium containing cephalexin. The spiral conformation of the elongated cells is therefore considered to rep...

The effect of a long length scale static inhomogeneity on spiral wave dynamics is studied in the two-dimensional complex Ginzburg-Landau equation. We find that the inhomogeneity leads to the formation of a dominant spiral domain that suppresses other spiral domains, and that the spiral vortices slowly drift in the presence of an inhomogeneity with a velocity that is proportional to the local pa...

Spiral Architecture is a relatively new and powerful approach to general purpose machine vision system. On this novel architecture, image rotation is achieved by Spiral Multiplication. However, the general image rotation on Spiral Architecture has two effects. One is scaling segmentation and the other is rotation. This paper presents an algorithm to achieve image rotation without scaling on Spi...

The influence of circularly polarized electric fields (CPEFs) on the stability of multiarmed spiral waves is investigated. It is shown that CPEFs can change the period of the multiarmed spirals. The average period is an important quantity of multiarmed spiral and it must be larger than a threshold for stable multiarmed spiral. After a counter-rotating CPEF with suitable amplitude and period is ...

BACKGROUND Soluble human leucocyte antigen-G (sHLA-G) is secreted by extravillous trophoblast (EVT) and has roles in regulating immune cells within the decidua. HLA-G expression on EVT increases as they approach uterine spiral arteries and we have suggested that sHLA-G may be important in the remodelling of these vessels. The autocrine role of sHLA-G in regulating trophoblast function at this c...

Atomically thin two-dimensional (2D) layered materials, including graphene, boron nitride, and transition metal dichalcogenides (TMDs), can exhibit novel phenomena distinct from their bulk counterparts and hold great promise for novel electronic and optoelectronic applications. Controlled growth of such 2D materials with different thickness, composition, and symmetry are of central importance t...

objective: to study the accuracy of spiral tomography in the determination of implant angulation. materials and methods: eighteen gutta-percha filled points on dry mandibles were selected for implant placement. a translucent acrylic template was fabricated for each mandible. after preparing tomographic images (2 mm slice thickness, cranex tome), the ideal axis of the implant was traced. the ang...

the vast majority of mandibular second molars have two roots with three root canals; however, variations in molar root canal anatomy are not uncommon. to the best of our knowledge, four rooted mandibular second molar with three mesial roots and one distal root has never been reported. herein, we present the endodontic management of a four rooted mandibular second molar tooth, diagnosed with the...