Growth differentiation factor 15 (GDF15), a member of the transforming growth factor‑β family, is stress‑induced cytokine. Under normal circumstances, expression GDF15 low in most tissues. It highly expressed during tissue injury, inflammation, oxidative stress and cancer. has been established as biomarker patients with cancer, associated cancer cachexia (CC) poor survival. CC multifactorial me...

The c-Myb transcription factor regulates the proliferation and differentiation of hematopoietic cells, and activated alleles of c-myb induce leukemias and lymphomas in animals. Relatively minor changes in the structure of c-Myb protein change the genes that it regulates and can unleash its latent transforming activities. Here, quantitative assays were used to analyze the alternative splicing of...