In this study, we analysed the possible influence of the c.419-43delT BMPR2 variant in patients with Graves' disease (GD), in a molecular basis, focusing our efforts on possible alterations in the mRNA processing and synthesis. The molecular assessment of this variant in patients with GD would shed light on the association between the BMPR2 gene and the disease. The variant was detected in 18%,...

Introduction: Boron neutron capture therapy (BNCT) is a method of cancer treatment and potentially, two borono-L-phenylalanine (BPA) and sodium borocaptate (BSH) are used in BNCT as common boron carriers. Some previous studies have shown that the dose rate is directly related to boron concentration in the tissue. This study aimed to simulate the structure of boron carriers and brain tumor compo...

Abstract Background Accelerated long-term forgetting has been identified in preclinical Alzheimer’s disease (AD) and is attributed to a selective impairment of memory consolidation which the hippocampus plays key role. As blood may contain multiple senescence-related factors that involved neurogenesis synaptic plasticity hippocampus, we tested whether there an association between blood-borne ac...

background:  we determined the blood lipid-lowering effects ofeicosapentaenoic acid (epa) on hypertriglyceridemic subjects with leu162/val in exon 5 and g/c in intron7 polymorphism of peroxisome proliferator-activated receptor alpha (pparα)genotypes that, to our knowledge, have not been previously studied. methods:  a total of170 hypertriglyceridemic subjects were enrolled and genotyped for ala...