Drosophila CAF1-55 protein is a subunit of the Polycomb repressive complex PRC2 and other protein complexes. It is a multifunctional and evolutionarily conserved protein that participates in nucleosome assembly and remodelling, as well as in the epigenetic regulation of a large set of target genes. Here, we describe and analyze the duplication of Caf1-55 in the obscura group of Drosophila. Para...

Jeffrey Adams, University of Maryland. The Chevalley Involution for Real Groups, with applications to the Fubini-Schur Indicator. The Chevalley involution of a complex group is unique up to conjugation, and takes any algebraic representation to its contragredient. The analogue over local fields is subtle. We prove that the Chevalley involution is defined over R, and with an appropriate conditio...

Polycomb repressive complex 2 (PRC2) deposits repressive epigenetic marks that silence inappropriate gene expression programs. Recent work from DelgadoOlguín et al1 in conjunction with studies from other laboratories2–4 show that PRC2 activity in cardiac progenitors influences growth and gene expression of mature cardiomyocytes. These studies illustrate the power of epigenetic mechanisms to ret...

PURPOSE This study examined ethnic differences in childhood and adolescent sexual abuse and the effect on teenage pregnancy rates. METHODS A 20-page questionnaire elicited information about women's sexual and pregnancy history, high-risk behaviors, and sexual abuse, based a modified version of the Koss and Oros Sexual Experiences Survey. Over 1,900 women between 18 and 22 years old were recru...

This study examined the role of family environment in determining early or later adolescent sexual behavior. Data were obtained from a 2-wave panel survey during 1989-1990, in the Brighton and Hove areas of Sussex, England. Interviews were conducted among 302 mother-adolescent pairs in the first wave and 255 pairs in the second follow-up wave. The study explored the links between intrafamily...

BACKGROUND We present a long-term safety, immunogenicity, and effectiveness study of a quadrivalent human papillomavirus (HPV4) vaccine. METHODS Sexually naive boys and girls aged 9 to 15 years (N = 1781) were assigned (2:1) to receive HPV4 vaccine or saline placebo at day 1 and months 2 and 6. At month 30, the placebo group (n = 482) received HPV4 vaccine following the same regimen and both ...

OBJECTIVE To determine the proportions of female participants in research studies selected to inform the development of national clinical guidelines and to assess these against the proportions of women affected by the conditions. METHODS We assessed 392 published articles, involving a total of 5.2 million participants, cited as references in five influential clinical guidelines addressing the...

Polycomb group (PcG) proteins regulate and maintain expression pattern of genes set early during development. Although originally isolated as regulators of homeotic genes, PcG members play a key role in epigenetic mechanisms that maintain the expression state of a large number of genes. All members of the two polycomb repressive complexes (PRC1 and PRC2) are conserved during evolution and while...

BACKGROUND Child feeding recommendations include breastfeeding beyond 12 months, however, some researchers have reported increased rates of malnutrition in breastfed toddlers. A negative association between growth and breast-feeding may reflect reverse causality; that is, the outcome (growth) is a determinant of the predictor (breastfeeding), and not vice versa. We examined this question with d...

It is commonly accepted that tree form has an impact on the productivity of single-grip harvesters. However, it remains unclear, which elements of tree form are significant and to what degree they impact harvesting productivity. This is of particular importance in hardwood dominated stands, where hardwood trees often exhibit complex and variable stem and crown architecture that can complicate a...