Surface topography is increasingly being recognized as an important factor to control the response of cells and tissues to biomaterials. In the current study, the aim was to obtain deeper understanding of the effect of microgrooves on shape and orientation of osteoblast-like cells and to relate this effect to their proliferation and osteogenic differentiation. To this end, two microgrooved poly...

A period from 1890 to 1930's roughly corresponds to active investigations in the United States into grooves on the occlusal surface of the teeth by such men as BLACK [5], BODECKER [6-9], HYATT [12-20] and DIAMOND[11]. Our concept of the morphology of the occlusal grooves has been developed and fostered by these pioneering workers. The occlusal grooves are usually of twofold : one is what is ter...

BACKGROUND The integrity of bone-cement interface is very important for the stabilization and long-term sustain of cemented prosthesis. Variations in the bone-cement interface morphology may affect the mechanical response of the shape-closed interlock. METHODS Self-developed new reamer was used to process fresh pig reamed femoral canal, creating cortical grooves in the canal wall of experimen...

Immobilization of cells inside microfluidic devices is a promising approach for enabling studies related to drug screening and cell biology. Despite extensive studies in using grooved substrates for immobilizing cells inside channels, a systematic study of the effects of various parameters that influence cell docking and retention within grooved substrates has not been performed. We demonstrate...

Owing to the enhancement of surface effects at the micro-scale, patterned grooves on a micro-channel floor remain a powerful method to induce helical flows within a pressure driven system. Although there have been a number of numerical studies on geometrical effects concerning fluid mixing within the staggered herringbone mixer, all have focused mainly on the groove angle and depth, two factors...

Surface patterning (micro-moulding) of dense, biomimetic collagen is a simple tool to produce complex tissues using layer-by-layer assembly. The aim here was to channelise three-dimensional constructs for improved perfusion. Firstly, collagen fibril accumulation was measured by comparative image analysis to understand the mechanisms of structure formation in plastically compressed collagen duri...

AIM The objective of this in vivo experiment is to propose an innovative therapeutic concept using a light-induced fluorescence evaluator for diagnosis and treatment (LIFEDT) that is based on the imaging and autofluorescence of dental tissues. BACKGROUND Processes with the aim of diagnosing carious lesions in the initial stage with optimum sensitivity and specificity employ a wide variety of ...

In an effort to develop a permissive environment for neural stem cell differentiation, directional growth of astrocytes has been achieved on polymer substrates in vitro. Manipulating a combination of physical and chemical cues, astrocyte adhesion and alignment in vitro were examined. To provide physical guidance, micropatterned polymer substrates of polystyrene (PS) were fabricated. Laminin was...

Palato gingival grooves, also called palatoradicular grooves or radicular lingual grooves are developmental anomalies in which an infolding of the inner enamel epithelium and Hertwig’s epithelial root sheath create a groove that passes from the cingulam and extend varying distances apically on to the root. The purpose of this study was to determine the prevalence of palato gingival groove in ma...