PURPOSE Single dose gadolinium (Gd) enhanced fluid-attenuated inversion recovery (FLAIR) is helpful for visualizing superficial parenchymal metastases. However, the usefulness of FLAIR with a higher dose of Gd is uncertain. The aim of our study was two-folds: first, to prove that the signal to noise ratio (SNR) of small brain metastases is higher than large brain metastases on double-dose (DD) ...

Glucocorticoids (GCs) generally stimulate gene transcription via consensus glucocorticoid response elements (GREs) located in the promoter region. To identify the GRE in the rat tyrosine hydroxylase (TH) gene promoter, we transiently transfected PC12 cells with a 9-kilobase (kb) TH promoter-luciferase (Luc) construct. Dexamethasone (Dex) stimulated Luc activity, which was abolished by mifeprist...

Composite pipes, which are widely used for transporting fluids, have a high strength, good impermeability and strong resistance to external pressure. Because the pipe bears sustained load, its constituent materials usually possess time-dependent properties, creep phenomenon unavoidably occurs in composite pipes long run. The aim of this study is propose analytical viscoelastic solutions, then a...

DNA repair takes place in the context of chromatin. Previous studies showed that histones impair base excision repair (BER) of modified bases at both the excision and synthesis steps. We examined BER of uracil in a glucocorticoid response element (GRE) complexed with the glucocorticoid receptor DNA binding domain (GR-DBD). Five substrates were designed, each containing a unique C-->U substituti...

OBJECTIVE To compare total left ventricular mass assessment using steady state free precession (SSFP) and inversion recovery fast gradient echo (IR GRE) imaging and further to assess the influence of contrast dosage on mass by IR GRE and its implications on relative infarct size assessment with both methods. METHODS Forty-three patients with first documented myocardial infarction and single v...

Pipe-in-Pipe (PIP) technology has been studied significantly owing to its superior performance in deep-water and high-pressure high temperature fields than conventional single pipe. The PIP system excellent track record of mitigating flow assurance problems from subsea wells through maintenance the fluid's It also applied marine environment where pipe cannot perform. However, complex interactio...

1 Grup de Recerca en Addiccions Clínic (GRAC-GRE), Hospital Clínic de Barcelona, IDIBAPS, Red de Trastornos adictivos (RETICS), Barcelona, Spain, 2 Grup de Recerca en Addiccions Clínic (GRAC-GRE), Hospital Clínic de Barcelona, Fundació Clínic per la Recerca Biomèdica, Red de Trastornos adictivos (RETICS), Barcelona, Spain, 3 Institute of Health and Society, Newcastle University, Newcastle, UK, ...

PURPOSE Clinical MRI patients typically experience elevated acoustic noise levels of 80-110 dB(A). In this study, standard clinical turbo spin echo (TSE) and gradient echo (GRE) sequences were optimized for reduced acoustic noise at preserved diagnostic image quality. METHODS The physical sources of acoustic noise generation in an MRI gradient coil were analyzed. A sequence conversion algorit...

The study's objective is to evaluate the enhanced effect of Ghrelin (GRE) on sperm analysis and antioxidant system in male rats after inducing hyperthyroidism by L–thyroxin. (50 males) were split into five groups. first group consisted 10 that given normal saline for 30 days S.C set as a control group. While second (positive group) was with S.C, third at dose (0.5nmol/100μl saline) fourth (1nmo...