Background & aim: There are conflicting results regarding the benefit of gonadotropin releasing hormone (GnRH) agonist treatment on frozen embryo transfer (FET) outcome. No study was found to compare pregnancy outcome between patients undergoing short and long acting types of GnRH agonist for FET cycles. This study aimed to assess the effectiveness of short and long ac...

STUDY QUESTION Do mental distress and mood fluctuations in women undergoing GnRH agonist and GnRH antagonist protocols for assisted reproductive technology (ART) differ depending on protocol and the personality trait, neuroticism? SUMMARY ANSWER ART treatment did not induce elevated levels of mental distress in either GnRH antagonist or agonist protocols but neuroticism was positively associa...

Molecular dynamics (MD) simulations can provide a detailed view of molecule behaviour at an atomic level, which be useful when attempting to interpret experiments or design new systems. The decapeptide gonadotrophin-releasing hormone I (GnRH-I) is known control fertility in mammals for both sexes. It was previously shown that inoculation with silica nanoparticles (SiNPs) coated GnRH-I makes eff...

OBJECTIVE To evaluate viability of luteinized granulosa cells obtained from patients triggered with either GnRH agonist or hCG and to assess the secretion of steroids and vascular endothelial growth factor (VEGF) by cultured luteinized granulosa cells in the presence or absence of hCG. DESIGN Prospective, randomized controlled trial. SETTING University-based fertility center. PATIENT(S) A...

Two experiments were conducted over 3 yr to determine pregnancy rates in beef heifers after a timed AI in response to the 7-11 Synch protocol. In Exp. 1, 179 heifers were either fed melengestrol acetate (MGA; 7-11 Synch) or given an intravaginal progesterone (P4)-releasing insert [controlled intravaginal drug releasing device (CIDR); 7-11 CIDR] for 7 d. Prostaglandin F2αwas administered on the ...

BACKGROUND In view of the discrepancies about the GnRH antagonist (GnRH-ant) ovarian stimulation protocols having some potential advantages compared with the GnRH agonist (GnRH-a) protocols in poor ovarian responders IVF/ICSI, a meta-analysis of the published data was performed to compare the efficacy of GnRH-ant versus GnRH-a protocols for ovarian stimulation in IVF poor response patients. M...

OBJECTIVE To compare antimüllerian hormone (AMH) and antral follicle count (AFC) as predictors of ovarian response to controlled ovarian stimulation at individual fertility clinics. DESIGN Retrospective analysis of individual study center data in two multicenter trials. Centers that provided >10 patients were included in the analysis. SETTING A total of 19 (n = 519 patients) and 18 study ce...

The aim of this study is to evaluate the feasibility and safety of random-start controlled ovarian hyperstimulation (COH) for emergency fertility preservation, regardless of the phase of the menstrual cycle. A self-controlled pilot clinical trial (NCT01385332) was performed in an acute-care teaching hospital and in two private reproductive centers in Barcelona, Spain. Eleven egg donors particip...

The GnRH analogue has been shown to be effective in the treatment of precocious puberty when given as a daily subcutaneous injection. We studied the effectiveness of a long-acting GnRH analogue, Triptoreline, for the treatment of central precocity, by suppressing gonadotropin and estradiol secretion in three children with true precocious puberty. One month after single dose intramuscular i...