MOTIVATION Analysis of high-throughput proteomic/genomic data, in particular, surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS) data and microarray data, has led to a multitude of techniques aimed at identifying potential biomarkers. Most of the statistical techniques for comparing two groups are based on qualitative measures such as P-value. A quantit...

Aql X-1 is a soft X-ray transient source and emits type I X-ray bursts. A spectral state transition was observed with RXTE during its outburst decay in February and March 1997. Its 10-30 keV and 5-10 keV count rate ratio increased suddenly when its luminosity was between (4-12) E35 ergs/s, assuming a 2.5 kpc distance. Spectral fitting with a model composed of a blackbody and a power-law compone...

In disease studies, family-based designs have become an attractive approach to analyzing next-generation sequencing (NGS) data for the identification of rare mutations enriched in families. Substantial research effort has been devoted to developing pipelines for automating sequence alignment, variant calling, and annotation. However, fewer pipelines have been designed specifically for disease s...

Limitations in the sensitivity and speed of conventional methods have triggered the increased use of nucleic acid amplification technologies for diagnosing tuberculosis. We recently described the universal sample processing (USP) method, which utilizes PCR, smear microscopy, and culture for diagnosing tuberculosis (3). Here we compared the efficiency of the USP method for isolation of DNA (refe...