The importance of colostrum for the growth and health of newborn offspring is well known. In bovine colostrum, the antibody (immunoglobulin) complement system provides a major antimicrobial effect against a wide range of microbes and confers passive immunity until the calf's own immune system has matured. Bovine serum and lacteal secretions contain three major classes of immunoglobulins: IgG, I...

1. This study presents an easy protocol to measure the amount of immunoglobulins from the blood serum of different bird species in the wild ( Ficedula hypoleuca Pallas, Parus caeruleus L., Lanius meridionalis Temminkck, Lanius collurio L., Athene noctua Scopoli and Falco tinnunculus L.) by direct enzyme-linked immunosorbent assay, ELISA using commercial antichicken antibodies. 2. Additionally, ...

The sera of patients with small cell carcinoma of the lung (SCCL) and an associated visual paraneoplastic syndrome (VPNS) have high titer immunoglobulins that react with retinal ganglion cells and with cloned lines of the SCCL. The immunoglobulins in the sera of two patients with SCCL and VPNS reacted with at least one common antigen shared by neural cells and cloned lines of the SCCL. The mole...

Infection and protein calorie malnutrition frequently coexist (Smythe, 1958; Brown, 1965; Phillips and Wharton, 1968), and though it is apparent that infection may affect nutrition adversely, it is difficult to prove that malnutrition is a factor in poor response to infection. In 1965 the World Health Organization Expert Committee on nutrition stated: 'The concept that malnutrition could make m...

This book represents a collection of papers presented by a group of leading vertebrate embryologists. Ciba Foundation Symposia have a well-deserved reputation for announcing the most advanced results in a field and the present volume is no exception. The last ten years have seen research in embryogenesis advance across a broad front and the papers published here survey the whole field. A centra...

Examination of 300 patients suffering from endogenous uveitis revealed raised levels of IgG in 24 per cent, IgA in 17 per cent, and IgM in 10 per cent. A raised level of one or more immunoglobulins was found more frequently in anterior uveitis than in the posterior form (44 compared with 24 per cent), in bilateral cases (47 compared with 35 per cent), and in relation to certain general diseases...

introduction: polyclonal antibodies are required to be affinity purified. improved purification methods of polyclonal antibody provide an opportunity to pick the most purified immunoglobulins as a primary or secondary antibody in immunoassays that are included in many vaccine studies. two common techniques for purifying proteins is salt precipitation and chromatography purification. our work fo...

In 1946, when I was starting work as a research student under the supervision of Dr. F. Sanger, the second edition of Karl Lansteiner’s book ‘The Specificity of Seriological Reactions’ (1) reached England. In it was summarised the considerable body of information available on the range of antibody specificity and much of it was Landsteiner’s own work or by others using his basic technique of pr...

Intravenous Immunoglobulins (IvIg) are often administered to critically ill patients more as an act of faith than on the basis of relevant clinical studies. This particularly applies to the treatment of sepsis in adult patients, in whom the current guidelines even recommend against their use, despite that many studies demonstrated either their beneficial effects in different subsets of patients...