Glut-1 deficiency syndrome (Glut-1 DS, OMIM #606777) is characterized by infantile seizures, developmental delay, acquired microcephaly and hypoglycorrhachia. It is caused by haploinsufficiency of the blood-brain barrier hexose carrier. Heterozygous mutations or hemizygosity of the GLUT-1 gene cause Glut-1 DS. We generated a heterozygous haploinsufficient mouse model by targeted disruption of t...

The aim of the study was to investigate the correlation of glucose transporter-1 (Glut-1) and glucose transporter-3 (Glut-3) expression with F-18 FDG uptake in pulmonary inflammatory lesions.Twenty-two patients with pulmonary inflammatory lesions underwent positron emission tomography/computed tomography (PET/CT) examination preoperatively, and Glut-1 and Glut-3 expression were detected by immu...

Andrographolide has been shown to have a pharmacological effect as an antidiabetic. Nevertheless, the comprehensive mechanism of action yet be determined. is primary component sambiloto herb (Andrographis paniculata (Burm.f.) Nees), in which simple isolation process can obtain high yields. This study aimed explain anti‐diabetic andrographolide compared pioglitazone (a positive control) on gluco...

The second ASPET-Ray Fuller Symposium was held in London, Ontario, Canada at Spencer Hall on March 24–26, 2000. This symposium focused on three main themes: interaction of the insulin signaling pathway with the cytoskeleton, nontyrosine kinase-mediated insulin receptor (IR) signaling and the specificity of the response to insulin, and the interaction between metabolism and hemodynamics. Domenic...

Background: Type 2 diabetes mellitus (DM) has many complications associated with increased morbidity and mortality. Cardiovascular are one of these serious complications. Therefore, there is a need for early effective management to hamper them. This study aimed evaluate the cardioprotective efficacy metformin myoinositol combination through exploring underlying mechanisms in type DM rat model. ...

background: to evaluate the effect of exendine-4 (ex-4), a glucagon-like peptide 1 (glp-1) receptor agonist, on the differentiation of insulin-secreting cells (ipcs) from rat adipose-derived mesenchymal stem cells(admscs). materials and methods: in this experimental study, admscs were isolated from rat adipose tissue and exposed to induction media with or without ex-4. after induction, the exis...

Glucose transporter (GLUT) proteins play a key role in the transport of monosaccharides across cellular membranes, and thus, blood sugar regulation and tissue metabolism. Patterns of GLUT expression, including the insulin-responsive GLUT4, have been well characterized in mammals. However, relatively little is known about patterns of GLUT expression in birds with existing data limited to the gra...