نتایج جستجو برای: glucose effect

تعداد نتایج: 1788918  

Journal: :international journal of reproductive biomedicine 0
sedigheh soheilykhah mahdie mogibian sodabeh rahimi-saghand maryam rashidi saeideh soheilykhah maryam piroz

background: gestational diabetes mellitus (gdm) is the most common metabolic complications of pregnancy and causes fetal mortality and morbidity. therefore early diagnosis of gdm is necessary to reduce maternal and fetal morbidity and to help prevent or delay the onset of type 2 diabetes objective: this prospective study was carried out to determine the incidence of gdm in yazd and to assess th...

Journal: :The Journal of biological chemistry 2004
Renaud Dentin Jean-Paul Pégorier Fadila Benhamed Fabienne Foufelle Pascal Ferré Véronique Fauveau Mark A Magnuson Jean Girard Catherine Postic

Hepatic glucokinase (GK) catalyzes the phosphorylation of glucose to glucose 6-phosphate (G6P), a step which is essential for glucose metabolism in liver as well as for the induction of glycolytic and lipogenic genes. The sterol regulatory element-binding protein-1c (SREBP-1c) has emerged as a major mediator of insulin action on hepatic gene expression, but the extent to which its transcription...

Journal: :American journal of physiology. Endocrinology and metabolism 2006
Hanae Yamazaki William Philbrick Kathleen C Zawalich Walter S Zawalich

The acute and chronic effects of 20 mM glucose and 10 microM carbachol on beta-cell responses were investigated. Acute exposure of rat islets to 20 mM glucose increased glucose usage rates and resulted in a large insulin-secretory response during a dynamic perifusion. The secretory, but not the metabolic, effect of 20 mM glucose was abolished by simultaneous exposure to 100 microM diazoxide. Gl...

2011
Michael S. Scully Tatiana A. Ort Ian E. James Peter J. Bugelski Dorie A. Makropoulos Heather A. Deutsch Elsbet J. Pieterman Anita M. van den Hoek Louis M. Havekes William H. duBell Joshua D. Wertheimer Kristen M. Picha

Patients treated with recombinant human Epo demonstrate an improvement in insulin sensitivity. We aimed to investigate whether CNTO 530, a novel Epo receptor agonist, could affect glucose tolerance and insulin sensitivity. A single administration of CNTO 530 significantly and dose-dependently reduced the area under the curve in a glucose tolerance test in diet-induced obese and diabetic mice af...

Background: Diabetes mellitus (DM) is a common chronic disease with diverse complications. About 10% of the earth's population suffer from this disease. For smart control of the blood glucose in DM patients, an artificial pancreas was designed and simulated by a predictive sliding mode controller considering the time delay of insulin effect. Method: In this method, one of the time-delay glucos...

Journal: :The Journal of clinical investigation 1988
H Miyoshi G I Shulman E J Peters M H Wolfe D Elahi R R Wolfe

Recent studies have established the existence of substrate cycles in humans, but factors regulating the rate of cycling have not been identified. We have therefore investigated the acute response of glucose/glucose-6P-glucose (glucose) and triglyceride/fatty acid (TG/FA) substrate cycling to the infusion of epinephrine (0.03 microgram/kg.min) and glucagon. The response to a high dose glucagon i...

2010
Dennis T. Villareal Heather Robertson Graeme I. Bell Bruce W. Patterson Hung Tran Burton Wice Kenneth S. Polonsky

OBJECTIVE Common variants in the gene TCF7L2 confer the largest effect on the risk of type 2 diabetes. The present study was undertaken to increase our understanding of the mechanisms by which this gene affects type 2 diabetes risk. RESEARCH DESIGN AND METHODS Eight subjects with risk-conferring TCF7L2 genotypes (TT or TC at rs7903146) and 10 matched subjects with wild-type genotype (CC) unde...

2015
RM Røge S Klim SH Ingwersen MC Kjellsson NR Kristensen

In recent years, several glucagon-like peptide-1 (GLP-1)-based therapies for the treatment of type 2 diabetes mellitus (T2DM) have been developed. The aim of this work was to extend the semimechanistic integrated glucose-insulin model to include the effects of a GLP-1 analog on glucose homeostasis in T2DM patients. Data from two trials comparing the effect of steady-state liraglutide vs. placeb...

Journal: :physiology and pharmacology 0
saeed esmaeili-mahani department of biology, faculty of sciences, shahid bahonar university of kerman, kerman, iran zahra hajializadeh laboratory of molecular neuroscience, kerman neuroscience research center, kerman university of medical sciences, kerman, iran shima torkzadeh-mahani laboratory of molecular neuroscience, kerman neuroscience research center, kerman university of medical sciences, kerman, iran

introduction: g-proteins have an important role in the cell signaling of numerous receptors. the situation of g-proteins in health and disease and their critical role in the development of diabetic side effects is an interested scientific field. here, the changes in the expression of g-protein subunits (gαi, gαs and gβ) were evaluated in hyperglycemic situation of pc12 cells as a cellular model...

Journal: :علوم زیستی ورزشی 0
فاطمه مصلحی دانشگاه آزاد اسلامی واحد ساری-کارشناسی ارشد فیزیولوژی ورزشی پروین فرزانگی دانشگاه آزاد اسلامی واحد ساری-دکتری فیزیولوژی ورزشی سید جعفر موسوی دانشگاه آزاد اسلامی-واحد قائم شهر دکتری مدیریت ورزشی

the aim of this study was to investigate the effect of eight weeks of aerobic training along with milk supplement on glut4, glucose and insulin in overweight immature boys. for this purpose, 28 immature overweight boys (8 to 10 years) were selected according to the questionnaire of nutrition, exercise abilities, body mass index, health and welfare from volunteers. then, subjects were divided in...

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