نتایج جستجو برای: gliomas
تعداد نتایج: 10988 فیلتر نتایج به سال:
Abstract Gliomas have been classified into molecular (proneural, classical, mesenchymal) and neurodevelopmental (astrocyte, mesenchymal, neural progenitor cell (NPC), oligodendrocyte (OPC)) subtypes describing inter- intra-tumoral heterogeneity; however, the functional outcomes therapeutic implications of these has yet to be fully described. Metabolic reprogramming is a hallmark cancer, maligna...
Gliomas são os tumores cerebrais primários mais frequentes, representando de 70% todas as neoplasias do Sistema Nervoso Central. Tanto o diagnóstico como a classificação destes baseados nas características histopatológicas que, por vezes, difíceis definir. Apesar dos avanços na neurocirurgia, quimioterapia e radioterapia, prognóstico doentes com gliomas continua muito reservado. Nas últimas dua...
PURPOSE Differentiation of high-grade gliomas and solitary brain metastases is an important clinical issue because the treatment strategies differ greatly. Our study aimed to investigate the potential value of diffusion tensor imaging (DTI) in differentiating high-grade gliomas from brain metastases using a meta-analytic approach. MATERIALS AND METHODS We searched Pubmed, Embase and the Cochr...
OBJECTIVE Malignant gliomas are the most common primary tumors of the central nervous system and the prognosis of patients with gliomas is poor. The combination of interferon-bata (IFN-β) and temozolomide (TMZ) has shown significant additive antitumor effects in human glioma xenograft models. Considering that the poor survival of patients with human malignant gliomas relates partly to the inabi...
Inter-individual variability causing elevated signaling of receptor tyrosine kinases (RTK) may have hampered the efficacy of targeted therapies. We developed a molecular signature for clustering adult diffuse gliomas based on the extent of RTK pathway activities. Glioma gene modules co-expressed with NF1 (NF1-M), Sprouty (SPRY-M) and PTEN (PTEN-M) were identified, their signatures enabled robus...
Tissues from 22 patients with glioma and 7 patients with normal white matter were used in this study. First we determined the proliferating area in the tumor tissue by evaluating the growth fraction (GF). Second we determined the mean number of cells and measured the intercapillary distance in a modified tumor cord in the proliferating area by using the texture analyzing system and Voronoi's me...
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