A reverse phase highperformance liquid chromatographic (RP-HPLC) method in gradient mode has been developed and evaluated for its ability to simultaneously establish the level of known impurities as well as the unknown impurities in pioglitazone and glimepiride tablets. The best separation was achieved on Eclipse XDB-C8, 5m, 4.6  150mm column. Use of 0.1N sodium dihydrogen phosphate dihydrate...

Objectives: Our objective was to study the effects of Ficus benghalensis on cognitive behavior and oxidative stress in diabetic rats compare with vitamin C glimepiride. Methods: Wistar either sex randomized into five groups by streptozocin (STZ), non-diabetic (distilled water) (n=10). Subgroup division (F. dose I II, i.e., 50 mg/kg 100 mg/kg; Vitamin glimepiride 0.5 mg/kg) were done. Each drug ...

in order to enhance in vitro dissolution and content uniformity of poorly soluble drug glimepiride by preparing solid dispersions using modified solvent fusion method, solid dispersions of drug were prepared by modified fusion solvent method using peg 6000 and pvp k25 (as carrier). eight batches (f1-f8) were prepared by factorial design (23) by taking three factors i.e. the concentration of: dr...

Diabetes mellitus is a metabolic disorder characterized by hyperglycemia, glycosuria, and sometimes ketonemia. The present study was carried out to assess prescribing practice and general trend of diabetes among patients at the Bombay Hospital, Indore. Prescriptions and complete records of diabetic patients were monitored and data was filed as per WHO prescription proforma. The study revealed t...

STUDIES Comparison of canagliflozin versus glimepiride (study A): Cefalu WT, Leiter LA, Yoon KH, Arias P, Niskanen L, Xie J, Balis DA, Canovatchel W, Meininger G: Efficacy and safety of canagliflozin versus glimepiride in patients with type 2 diabetes inadequately controlled with metformin (CANTATA-SU): 52 week results from a randomised, double-blind, phase 3 non-inferiority trial. Lancet 382:9...

A new simple, fast accurate and reproducible reverse phase high performance liquid chromatographic method has been developed and validated for simultaneous estimation of Metformin Hydrochloride and Glimepiride from tablet dosage form. The method was developed using Waters HPLC system on C18 column (Spherisorb ODS 2: 250mm x 4.6 μm) using a mixture of 25mM Phosphoric Acid pH 3.0 (with KOH) and A...

BACKGROUND Poor control of type 2 diabetes results in substantial long-term consequences. Studies of new diabetes treatments are rarely designed to assess mortality, complication rates and costs. We sought to estimate the long-term consequences of liraglutide and rosiglitazone both added to glimepiride. METHODS To estimate long-term clinical and economic consequences, we used the CORE diabete...

Introduction: T2DM is a group of metabolic disorders manifested by hyperglycemia as a result of insulin insufficiency and/or resistance. The main goal of antidiabetic therapies is to lower glucose levels, and therefore prevent development of diabetes complications. DPP-4 inhibitors (e.g. sitagliptin) are relatively new antidiabetic drugs which inhibit the activity of DPP-4 enzyme and therefore ...