RATIONALE The lower rectal gastrointestinal stromal tumor (GIST) is a rare entity and warrants special attentions because of the considerations of preserving of anal and urinal functions. Neoadjuvant therapy with imatinib mesylate (IM) has achieved great success in GIST, which potentially extends the applications of function-preserving minimally invasive surgical procedures. Transanal endoscopi...

Inflammatory myofibroblastic tumors (IMTs) and gastrointestinal stromal tumors (GISTs) are both spindle cell tumors, and occur rarely in the wall of the urinary bladder. In general, immunostaining allows differentiation of IMTs and GISTs. Most IMTs are positive for anaplastic lymphoma kinase (ALK) and negative for KIT, whereas most GISTs are ALK-negative and KIT-positive. Here, we describe a ca...

Gastrointestinal stromal tumors (GISTs) account for about 0.2% of all malignancy of gastrointestinal tumors and rarely arise in the rectum. We experienced three patients with large GISTs in the rectum. Case 1 (66-year-old man) underwent abdominoperineal resection (APR) for intrapelvic mass. The tumor was 90 mm and diagnosed to be a Kit-positive GIST. Case 2 (81-year-old woman) underwent right h...

PURPOSE In gastrointestinal stromal tumor (GIST), there is no biomarker available that indicates success or failure of therapy. We hypothesized that tumor-specific v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog (CKIT)- or platelet-derived growth factor receptor-α (PDGFRA)-mutant DNA fragments can be detected and quantified in plasma samples of patients with GIST. EXPERIMENTAL D...

BACKGROUND It is very rare that gastrointestinal stromal tumor (GIST) occurs in the sacrum. Only one case of GIST occuring in the sacral region, with intracranial metastasis, has been reported in the literature. Moreover, only few cases have been published in literature about its clonal origin. CASE PRESENTATION In this report, we present a rare case of GIST occuring in the sacrum and describ...

Introduction: Majority of mesenchymal tumors of gastrointestinal tract are Gastrointestinal Stromal Tumor (GIST). It is, however, a rare tumor, accounting for less than 1% of primary gastrointestinal (GI) neoplasms. Though, these tumors are refractory to conventional chemotherapy or radiotherapy but show a good response to targeted adjuvant chemotherapy with tyrosine kinase inhibitors following...

Cholangiolocellular carcinoma (CoCC) is a rare primary liver cancer. It is considered to originate from hepatic progenitor or stem cells. We report a rare case of a 74-year-old male with CoCC of the liver and duodenal gastrointestinal stromal tumor (GIST). Both tumors manifested tracer uptakes on F-18 fluorodeoxyglucose positron emission tomography/computed tomography (F-18 FDG PET/CT); however...

BACKGROUND Lymph node (LN) metastasis of gastrointestinal stromal tumors (GIST) is unusual. Unlike gastric adenocarcinomas, routine lymphadenectomy is not recommended unless there is no suspicion for LN metastasis. Herein, we report a case of GIST of the stomach with LN metastasis treated with distal gastrectomy with perigastric LN dissection followed by adjuvant imatinib therapy. CASE PRESEN...