The prohormone convertases (PCs) are processing enzymes that activate proproteins via cleavage at specific single or pairs of basic residues. The hypothalamic paraventricular nucleus (PVN) and supraoptic nucleus (SON) are primary sites of biosynthesis of several neuroendocrine hormone precursors, including provasopressin (pro-AVP), pro-oxytocin (pro-OT), and procorticotrophin-releasing hormone ...

mRNA-splicing presents an important regulatory step that contributes to the functional repertoire of all cell types and tissues. Profound changes in alternative splicing have also been revealed during embryonic stem cell (ESC) differentiation. Based on a genome-wide screen for pluripotency regulators, Ng and colleagues now identify SON as a new splicing regulator in the maintenance of human ESC...

A simple analytical model of a nanoscale fully depleted dualmaterial gate (DMG) SOI and SON MOSFETs has been developed and their performance comparison analysis is presented in this paper. An analytical model for the surface potential and threshold voltage has been developed both for these structures using a generalized 2D Poisson’s equation solution. The DMG SON MOSFET technology is found to h...

1. Introduction Handover (HO) is key procedure for ensuring that users can move freely within a network being connected to high quality services [1]. In currently deployed mobile networks, handover optimization is performed manually over a long time period-days or weeks. This approach is both time consuming and can not be carried out as often as needed. By introducing an online self-optimising ...

This special volume is focused upon a selection of the papers that were presented at the 9th International Conference on the Practice and Theory of Automated Timetabling (PATAT) in Son, Norway, between 28th and 31st August, 2012. The PATAT conferences are held biennially. This is the third occasion that we have employed the Annals of Operations Research as the forum for a revised and selected c...

Mutations to PKD1 and PKD2 are associated with autosomal dominant polycystic kidney disease (ADPKD). The absence of apparent PKD1/PKD2 linkage in five published European or North American families with ADPKD suggested a third locus, designated PKD3. Here we re-evaluated these families by updating clinical information, re-sampling where possible, and mutation screening for PKD1/PKD2. In the Fren...

OBJECTIVES Research on the family's contribution to the quality of life of persons with serious mental illness has largely focused on negative family interactions associated with poorer client outcomes. The purpose of this naturalistic study of aging mothers and adults with schizophrenia was to investigate prosocial family processes that potentially enhance, rather than detract from, the life s...

— Reducing the production costs associated with digital materials in the e-Learning area is a imperative need. One of the followed strategies is to build didactical materials as modular and reusable components, called digital Learning Objects (LO). Their most important advantage is their ability for integrating easily with other more complex LO to build didactical units or complete courses. In ...