OBJECTIVES We aimed to determine whether growth hormone (GH) resistance is present in patients with chronic heart failure (CHF) and whether it may be linked to the biochemical response to GH treatment. BACKGROUND Acquired GH resistance is a feature of severe illness, in particular, cachexia. In patients with CHF, the response to GH therapy appears to be variable. METHODS Biochemical markers...

The syndrome of adult GH deficiency and the effects of GH replacement therapy provide a useful model with which to study the effects of the GH/IGF-I axis on exercise physiology. Measures of exercise performance including maximal oxygen uptake and ventilatory threshold are impaired in adult GH deficiency and improved by GH replacement, probably through some combination of increased oxygen delive...

Herpesviruses form different gH/gL virion envelope glycoprotein complexes that serve as entry complexes for mediating viral cell-type tropism in vitro; their roles in vivo, however, remained speculative and can be addressed experimentally only in animal models. For murine cytomegalovirus two alternative gH/gL complexes, gH/gL/gO and gH/gL/MCK-2, have been identified. A limitation of studies on ...

In this issue of Circulation, Tajima et al 1 report that recombinant human growth hormone (GH) (3.5 mg z kg z d) given for 2 weeks, while not affecting baseline function, restored myocardial contractile reserve in cardiomyocytes isolated from rats 4 to 6 weeks after myocardial infarction (MI) compared with vehicle-treated post-MI rats. In addition, the peak of the Ca transient, which was normal...

OBJECTIVE AND DESIGN A decrease of GH levels below 2 microg/l after an oral glucose tolerance test (OGTT) is still currently accepted as the gold standard for assessing cure in surgically treated acromegaly. Whether glucose-induced suppression of GH is accompanied by a restoration of normal GH late rebound has not yet been evaluated in this disease. In order to assess the restoration of normal ...

This study aims at improving shearography non-destructive testing (NDT) of deep defects in thick composites with thermal loading. Instead conventional global heating (GH), the core idea is to apply novel spatially modulated (SMH) for NDT. In this paper, finite element method (FEM) has been used advance towards a quantitative inspection tool composites. Both GH and SMH have performed experimenta...

In the present study, primary mouse hepatocytes from 8- to 10-week-old virgin female Swiss-Webster mice were perfused with collagenase (100 U/ml) using the two-step method. Isolated hepatocytes were plated in a rat tail type I collagen sandwich configuration to examine the regulation of GH receptor (GHR) and GH-binding protein (GHBP) expression by GH and 17beta-estradiol (E2). After 48 h of ini...

BACKGROUND/AIMS Few data are available about parental concerns and psychosocial functioning of young children born small for gestational age (SGA) treated with growth hormone (GH). The present study focused on the perception of short stature and the concerns and expectations of the parents regarding GH treatment. METHODS Forty prepubertal short SGA children, randomized into a GH-treated and a...

OBJECTIVE Young adults with childhood-onset GH deficiency (GHD) have reduced memory and attention, which can be improved by treatment with GH. Little information is available on cognitive function in elderly GHD patients. DESIGN Single center, double-blind, randomized, placebo-controlled study of 52-week duration. METHODS Elderly GH therapy naïve GHD patients (n=34; age range 60-77 years) w...

1. Introduction It is not clear how different portions of the capsuloligaments and muscles contribute to GH stability. Since GH instabilities occur frequently in various shoulder injuries, it is important to understand the restraining forces provided by various structures in the GH-joint. A better understanding of the GH stiffness will also help improve existing shoulder models by including GH ...