B.H. Ali, Department of Pharmacology, Faculty of Medicine, Al-Arab Medical University, PO Box 7240, Benghazi (Libya) Results are means+SEM (n=5). a Gentamicin was injected intramuscularly daily for 6 days and serum obtained on the 7th day. b Captopril was injected intraperitoneally once and serum obtained 1 h later. c One unit is defined as amount of enzyme required to release 1 mmol of hippuri...

background and objective: gentimicin is an antibiotic from the family of aminoglycosides used in the treatment of infections resulted from gram-negative bacteria, the use of which is limited due to its nephrotoxicity. in this study the histological effect of cinnamon on the nephrotoxicity resulted from gentimicin in rats is investigated because of the antioxidant properties of cinnamon.material...

The frequent use of nonsteroidal anti-inflammatory drugs (NSAID) in combination with gentamicin poses the additional risk of nephrotoxic renal failure. Cyclooxygenase-1 (COX-1) is the main enzyme responsible for the synthesis of renal vasodilator prostaglandins, while COX-2 participates predominantly in the inflammatory process. Both are inhibited by non-selective NSAID such as indomethacin. Se...

The present study evaluates the nephroprotective effects of ursolic acid in a murine model of gentamicin induced renal damage. Wistar albino rats of either sex, weighing 150-200 g were divided into 5 groups; normal saline, gentamicin 80 mg/kg, intraperitoneally for 8 days, ursolic acid at 2, 5, and 10 mg/kg, per oral for 8 days, ursolic acid administered 3 days prior and concurrently with genta...

Implication for health policy/practice/research/medical education: Potential kidney protective effects of metformin, might have synergistic effect with some other antioxidants such as medicinal plants. Hypothesis Please cite this paper as: Rafieian-Kopaei M, Baradaran A. Combination of metformin with other antioxidants may increase its renoprotective efficacy. Hypothesis R ecently, much attenti...