Stress is associated with significant losses in the swine industry. Seasonal changes have been shown to affect stress resistance in several species of animals. In the present study, we examined the effect of two seasons (fall or winter) on plasma insulin, cortisol, and adrenocorticotrophin hormone (ACTH) levels from fasted normal and carrier pigs for stress susceptibility when submitted to a bl...

Background: Although the term cirrhotic cardiomyopathy expresses cardiac changes associating liver cirrhosis unrelated to its aetiology, hepatitis C virus HCV was suggested to play a role in cardiomyopathy and/or myocarditis. However the existence of such direct viral effect on the heart in HCV induced liver cirrhosis LC patients remains to be verified. Rationale of the current study was to fig...

Background: The pathogenesis of many diseases is correlated to irregularity in vascular endothelial growth factor (VEGF) expression. Results from several association studies show that variation in the level of VEGF expression is related to polymorphic sequences within the VEGF gene. Additionally, there are many studies showing that some gene polymorphisms significantly influence the pharmacokin...

Alcohol is one of the major risk factors for oral and pharyngeal cancer. The rate-limiting step in alcohol metabolism is the oxidation (activation) of ethanol to acetaldehyde by the alcohol dehydrogenases (ADHs). It has been hypothesized that individuals who are homozygous for the fast allele (ADH(1-1)(3)) are at greater risk for alcohol-related cancers. To test this hypothesis, we investigated...

CONTEXT A polymorphism of the GH receptor (GHR) gene resulting in genomic deletion of exon 3 (GHR-d3) has been associated with responsiveness to GH therapy. However, the data reported so far do vary according to the underlying condition, replacement dose, and duration of the treatment. OBJECTIVE, DESIGN: The aim of this study was to analyze the impact of the GHR genotypes in terms of the initia...

It has been reported that individuals who express GSTT1, the gene coding for the theta class of the glutathione S-transferases (GSTs), have an elevated risk of prostate cancer (CaP). This result is supported by studies that show glutathione conjugation of some xenobiotics by the GSTs can produce mutagenic intermediates. However, the potential role of environmental factors in modifying the risk ...

In these investigations, the yield stability of 14 winter bread wheat genotypes were analyzed. The experimental part trial was performed at three locations (Kragujevac, Kruševac and Sombor) during 2013/2014. AMMI analysis variance for grain showed that all sources variation (genotype, environment, their interaction) had a significant effect on expression this complex trait. total experiment, la...

OBJECTIVE To investigate whether variable antidepressant response may be influenced by an interaction between the serotonin transporter promoter polymorphism (5-HTTLPR) and antidepressant concentration. METHODS Elderly subjects with depression treated with paroxetine (n = 110) were genotyped and assessed with the Hamilton Rating Scale for Depression (HAMD). A mixed-effect analysis of repeated...

IMPORTANCE The apolipoprotein E (APOE [GenBank, 348; OMIM, 107741]) ε4 allele is a common and well-established genetic risk factor for Alzheimer disease (AD). Sleep consolidation is also associated with AD risk, and previous work suggests that APOE genotype and sleep may interact to influence cognitive function. OBJECTIVE To determine whether better sleep consolidation attenuates the relation...

We investigated the effects of XPG His1104Asp polymorphism (rs17655) on the risk of lung cancer and squamous cell carcinomas of the oropharynx, larynx and esophagus (SCCOLE). This population-based case-control study involves 611 new cases of lung cancer, 601 new cases of oropharyngeal, laryngeal and esophageal cancers, and 1,040 cancer-free controls. The XPG polymorphism was assayed by PCR-RFLP...