the present study was aimed to examine the association of bovine follicular stimulating hormone gene polymorphism with sperm quality traits including sperm volume (sv), sperm concentration (spco), total sperm (ts), fresh sperm motility (fsm), total fresh motile sperm (tfms), post thaw sperm motility (ptsm), total post thaw motile sperm (tptms), number of produced payout (npp), number of fresh m...

BACKGROUND TP53 mutations are the most common genetic alterations in human cancers. There are also several polymorphisms in both exons and introns of TP53 that may influence its anti-tumor functions and increase the risk of cancer development. Associations of the TP53 intron 6 G13964C polymorphism with increased risk of development of several cancers have been investigated in numerous studies, ...

Background: The decisive etiology of Oral squamous cell carcinoma (OSCC)  is still ambiguous, but we recognize the contribution of genetic aberration and environmental agent due to OSCC initiation. In the current study, we elucidate the potential impact of EGFR gene polymorphisms in the risk of OSCC in the southeast of Iran. Methods: Forty-eight OSCC patients along with 100 normal volunteers w...

BACKGROUND The angiotensin-converting enzyme (ACE) gene in humans has an insertion-deletion (I/D) polymorphic state in intron 16 on chromosome 17q23. This polymorphism has been widely investigated in different diseases. In this study we aimed to investigate the ACE I/D genotype frequency in hypertensive cases in Kashmiri population. MATERIALS AND METHODS We designed a case control study, wher...

BACKGROUND ABCA1 R219K single-nucleotide polymorphisms (SNPs) was related to Alzheimer disease (AD) but not Parkinson disease (PD). Here, we analyzed the associations among ABCA1 R219K distribution, serum biomarkers, AD, and PD in a population in northern China. MATERIAL AND METHODS We used the Mini-Mental State Examination (MMSE) and the Hoehn and Yahr scale (H-Y) to evaluate AD and PD progres...

Objective The aim of present study was to clarify the role of the peroxisome proliferator-activated receptor (PPAR) γ Pro12Ala and C161T polymorphisms in the pathogenesis of polycystic ovary syndrome (PCOS) and their influence on lipid and lipoprotein profiles of patients. MaterialsAndMethods The present cross-sectional study consisted of 50 women with PCOS, who referred to the Kermanshah Unive...

PURPOSE The aim of the study was to determine the association of macrophage migration inhibitory factor (MIF) gene polymorphisms with Vogt-Koyanagi-Harada (VKH) syndrome. METHODS A total of 600 Han Chinese VKH patients and 600 healthy controls were genotyped for rs755622 and rs2096525 of MIF by PCR-restriction fragment length polymorphism (PCR-RFLP) assay. Data were analyzed by χ(2) analysis....

background: previous studies have revealed significant differences between populations for genotypic frequencies of glutathione s-transferase t1 ( gstt1 ) and m1 ( gstm1 ) polymorphisms. in order to find the frequency of the null genotypes of gstm1 and gstt1 in iranian populations, the present study was carried out. methods: the total study subjects consisted of 1340 unrelated healthy muslims/i...