Targeting of the mucosal immune system of the genital tract with subunit vaccines has failed to induce potent and durable local CD8(+) T cell immunity, which is crucial for protection against many sexually transmitted viral pathogens, including HSV type 2 (HSV-2), which causes genital herpes. In this study, we aimed to investigate the potential of a novel lipopeptide/adenovirus type 5 (Lipo/rAd...

Pathological discharge from the genital tract and other signs of discomfort external genitalia are a common cause visit to gynecologist. The these disorders in most cases is vulvovaginal infection, accompanied (vaginitis) or not (vaginosis) by leukocyte reaction. Methods for treating infection predominantly local therapy systemic agents with highly selective antimicrobial activity. Since signif...

IL-1β has been implicated in the development of oviduct pathology during Chlamydia muridarum genital infection in the mouse model. The goal of this study was to characterize the role of IL-1 signaling and the inflammasome-activation pathways during genital chlamydial infection. Compared with control mice, IL-1R-deficient mice displayed delayed clearance and increased chlamydial colonization. Co...

Four hundred and seventy eight (478) individuals who exhibited some manifestation of chronic and debilitating illness including persistent cough, skin cancer and dermatitis, multiple lymph adenitis, diarrhea and enteritis, genital sore, urethritis, vaginitis and weight loss, were examined to establish relationships between human immunodeficiency virus infection (HIV) and digestive tract pathoge...

background and objective: this study was undertaken to assess the ability of standard urinalysis (ua) and hemocytometer white blood cell (wbc) counts for the diagnosis of urinary tract infection (uti) in patients with urinary symptoms. materials and methods: a total of 600 patients with symptoms of urinary tract infection were enrolled in this prospective study. standard ua, hemocytometer wbc c...

The functional role of CD4⁺CD25⁺Foxp3⁺ regulatory T cells (Tregs) in host responses to intracellular bacterial infection was investigated in an in vitro coculturing system and a murine model of Chlamydia muridarum genital tract infection. Remarkably, C. muridarum infection subverted the immune suppressive role of CD4⁺CD25⁺Foxp3⁺ Tregs; instead of hampering immune responses, Tregs not only promo...

Uterine lymphoma is a rare disease therefore, information regarding histologic type, immunophenotype of tumor cells and etiologic factors are limited. although secondary involvement of the genital tract occurs in up to 40% of cases• of disseminated lymphoma, lymphoma presenting with primary female genital tract . symptomatology is very unusual. We report a case of B-cell lymphoma in the ut...

Matrix metalloproteinases (MMP) are a family of host-derived enzymes involved in the turnover of extracellular matrix molecules. We have previously reported enhanced expression of matrix metalloproteinases in Chlamydia muridarum urogenital tract infection of female mice. Kinetics and patterns of MMP expression as well as enhanced expression in susceptible strains of mice in the prior study impl...

uterine lymphoma is a rare disease therefore, information regarding histologic type, immunophenotype of tumor cells and etiologic factors are limited. although secondary involvement of the genital tract occurs in up to 40% of cases• of disseminated lymphoma, lymphoma presenting with primary female genital tract . symptomatology is very unusual. we report a case of b-cell lymphoma in the uterine...

UNLABELLED A number of men receiving prolonged suppressive highly active antiretroviral therapy (HAART) still shed human immunodeficiency virus (HIV) in semen. To investigate whether this seminal shedding may be due to poor drug penetration and/or viral production by long-lived cells within male genital tissues, we analyzed semen and reproductive tissues from macaques chronically infected with ...