AIM To investigate the rate, risk factors, clinical course, and treatment outcomes of endophthalmitis following glaucoma drainage implant (GDI) surgery. METHODS A computerised relational database search was conducted to identify all patients who were implanted with Ahmed glaucoma valve (AGV) and developed endophthalmitis following surgery at the King Khaled Eye Specialist Hospital in Riyadh, ...

This article explains a new implementation of efficient D-Flip-Flop (DFF) using Gate-Diffusion-Input (GDI) technique, PowerPC, DSTC, and HLFF. This DFF design allows reducing power-delay product and area of the circuit, while maintaining low complexity of logic design. Performance comparison with other DFF design techniques is presented, with respect to gate area, number of devices, delay and p...

Corticosterone, the major stress hormone, plays an important role in regulating neuronal functions of the limbic system, though the cellular targets and molecular mechanisms of corticosteroid signaling are largely unknown. Here we show that a short treatment of corticosterone significantly increases AMPARmediated synaptic transmission and AMPAR membrane trafficking in pyramidal neurons of prefr...

Protein synthesis factor eIF2 delivers initiator tRNA to the ribosome. Two proteins regulate its G-protein cycle: eIF5 has both GTPase-accelerating protein (GAP) and GDP dissociation inhibitor (GDI) functions, and eIF2B is the guanine nucleotide exchange factor (GEF). In this study, we used protein-protein interaction and nucleotide exchange assays to monitor the kinetics of eIF2 release from t...

Prenylated Rab GTPases regulate intracellular vesicle trafficking in eukaryotic cells by associating with specific membranes and recruiting a multitude of Rab-specific effector proteins. Prenylation, membrane delivery, and recycling of all 60 members of the Rab GTPase family are regulated by two related molecules, Rab escort protein (REP) and GDP dissociation inhibitor (GDI). Biophysical analys...

an analytical nonlinear stress-strain model and a microscopic damage index for confined and unconfined concretes together with a macroscopic damage index for reinforced concrete (rc) structures under cyclic loading are proposed. in order to eliminate the problem of scale effect, an adjustable finite element computer program was generated to simulate rc structures subjected to cyclic loading. by...

Background: Irreversible electroporation (IRE) is a novel tumor ablation technique. IRE is associated with high electrical fields and is often reported in conjunction with thermal damage caused by Joule heating. For good response to surgery it is crucial to produce minimum thermal damage in both tumoral and healthy tissues named Non-Thermal Irreversible Electroporation(NTIRE). Non-thermal irrev...

The United States has two measures of economic output: gross domestic product (GDP) and income (GDI). While these are conceptually equivalent, their initial estimates differ because computed from different incomplete data sources. I study the difference, or “statistical discrepancy,” between GDP GDI in percent document three features. First, its size does not materially shrink on average as mor...

This paper presents logic style comparisons based on different logic functions and claimed modified Gate Diffusion Input logic (Mod-GDI) to be much more power-efficient than Gate Diffusion Input logic (GDI) and complementary CMOS logic design. However, DC and Transient analysis performed on more efficient modified Gate Diffusion Input logic (Mod-GDI) circuit realizations and a wider range of di...

Many genetic and molecular alterations, such as K-ras mutation and NF-kappaB activation, have been identified in pancreatic cancer. However, the mechanisms by which pancreatic cancer metastasizes still remain to be determined. Although we previously showed that the tropomyosin-related kinase B (TrkB) was significantly correlated with the development of liver metastasis, its function in pancreat...