This article provides an overview of (a) issues in definition and diagnosis of specific reading disabilities at the behavioral level that may occur in different constellations of developmental and phenotypic profiles (patterns); (b) rapidly expanding research on genetic heterogeneity and gene candidates for dyslexia and other reading disabilities; (c) emerging research on gene-brain relationshi...

the objective of the current study was to estimate the genetic parameters for body weight traits at different ages in iran-black sheep. data collected during a 24-year period (1984-2008) on body weight were used to model the growth trajectory and estimate genetic parameters. studied traits were birth weight (bw), weaning weight at 3 months of age (ww), 6 months weight (6mw), 9 months weight (9m...

Several factors influence the incidence and severity of cardiovascular disease, such as environmental exposures, medical adherence, and genetic polymorphisms. One of the genetic components is a heritable interindividual variation in platelet reactivity, which is greater in black individuals than whites. This correlates strongly with the historical observations that black individuals develop car...

MOTIVATION The genetic basis of complex traits often involves the function of multiple genetic factors, their interactions and the interaction between the genetic and environmental factors. Gene-environment (G×E) interaction is considered pivotal in determining trait variations and susceptibility of many genetic disorders such as neurodegenerative diseases or mental disorders. Regression-based ...

    Molecular epidemiology is a subdivision of medical science and epidemiology that emphases on the involvement of potential environmental and genetic risk factors, recognized at the molecular level, to the etiology and avoidance of sickness through populations. This arena has developed from the combination of molecular biology and traditional epidemiological research. Molecular...

in this research, 6517 records, collected by khojir sheep breeding station (tehran, iran), during 1991 to 2011 were used to estimate genetic parameters of lamb survival in zandi sheep. genetic parameters were estimated using 16 different models of animal model, sire and threshold models using reml procedures. the aic criterion was used to evaluate the models. the effects in the most suitable an...

the aim of the present study was the estimation of (co) variance components and genetic parameters for body weight of moghani sheep, using random regression models based on b-splines functions. the data set included 9165 body weight records from 60 to 360 days of age from 2811 moghani sheep, collected between 1994 to 2013 from jafar-abad animal research and breeding institute, ardabil province,...

Technical advances have improved the capacity to detect and quantify genetic variants, providing novel methods for the detection of rare mutations and for better understanding the underlying environmental factors and biological mechanisms contributing to mutagenesis. The polymerase chain reaction (PCR) has revolutionized genetic testing and remains central to many of these new techniques for mu...

Birthweight has implications for physical and mental health in later life. Using data from Caucasian twins collected in Australia, the Netherlands and the United States, and from East Asian twins collected in Japan and South Korea, we compared the total phenotypic, genetic and environmental variances of birthweight between Caucasians and East Asians. Model-fitting analyses yielded four major fi...

myocardial infarction (mi) and its major determinant, coronary artery disease (cad), are complex diseases arising from the interaction between several genetic and environmental factors. until recently, the genetic basis of these diseases was poorly understood. genome-wide genetic association studies have afforded a comprehensive insight into the association between genetic variants and diseases...