The goal of this study was to compare the pharmacokinetics of nicardipine hydrochloride orally disintegrating tablets and β-cyclodextrin inclusion complex with its conventional tablets. Forty-five rats were divided into three groups evaluating the effect of dosage forms on the pharmacokinetics of nicardipine hydrochloride. Blood samples were taken at predefined sampling points 0–24h after medic...

OBJECTIVES Levocetirizine HCl, a second-generation piperazine derivative and H1-selective antihistaminic agent, possesses few side effects. The first objective of the study was to compare and evaluate the taste-masking effect of different ratios of 2-hydroxypropyl-β-cyclodextrin and mannitol on levocetirizine HCl using an inclusion complex and solid dispersion, respectively. The second objectiv...

The objective of the present investigation was to evaluate potential of nanoemulsions as a coating material for the tablets. The nanoemulsion of size less than 100 nm was prepared using a simple and low-energy spontaneous emulsification method. Conventional tablets containing theophylline as a model hydrophilic drug were prepared. The theophylline tablets were coated with the nanoemulsion using...

The objective of the present study is to formulate and evaluate roxithromycin tablets employing roxithromycin (ROX) solid dispersions. Dispersions of ROX in mannitol were prepared by different techniques like physical mixing, melting method, melt solvent method, kneading technique and common solvent method with drug and carrier ratio of 1:1, 1:2, 1:4 and 1:9. ROX tablets were formulated employi...

background the dilution and rapid elimination of topically applied drugs due to the flushing action of saliva is a major difficulty in the effort to eradicate infections of oral cavity. utilization a proper delivery system for incorporation of drugs has a major impact on drug delivery and such a system should be formulated for prolonged drug retention in oral cavity. objectives the aim of the p...

this study was performed to design bilayer regioselective floating tablets of atenolol and lovastatin to give immediate release of lovastatin and sustained release of atenolol. bilayer floating tablets comprised two layers, i.e immediate release and controlled release layers. the immediate release layer comprised sodium starch glycollate as a super disintegrant and the sustained release layer c...

Glibenclamide (GBD), also known as glyburide, is an oral hypoglycemic of the sulfonylurea group that is frequently prescribed for the treatment of noninsulin dependent diabetes mellitus. The aim of this study was to assess the pharmaceutical quality of new formulations and four generic marketed glibenclamide tablets in Saudi Arabia in comparison with the innovator product (Daonil tablets). Fria...

There has been a significant and growing interest in chemical imaging of pharmaceutical tablets in recent years. Technology improvements and increased use has established chemical imaging as a means of providing information on certain critical quality parameters that is not readily addressable using other techniques. In addition to major pharmaceutical manufacturers, generic manufacturers and e...

Mobility as a Service (MaaS) applies the everything-asa-service paradigm of Cloud Computing to transportation: a MaaS provider offers to its users the dynamic composition of solutions of different travel agencies into a single, consistent interface. Traditionally, transits and data on mobility belong to a scattered plethora of operators. Thus, we argue that the economic model of MaaS is that of...