Three carbapenem-resistant Acinetobacter baumannii isolates were collected at a hospital in Buenos Aires, Argentina. Isoelectric focusing revealed multiple beta-lactamases, with two of the isolates showing identical profiles. A pI 6.9 carbapenemase with a molecular weight of 30 kDa was purified from one of these two isolates. The enzyme was predominantly a penicillinase, with its highest Vmax f...

Acinetobacter species have become important pathogens in health care settings and are now responsible for substantial mortality and mortality. The resistance among Acinetobacter spp. has also been continuously rising since 2000. Multidrug-resistance (MDR), is defined as simultaneous resistance to fluoroquinolones, aminoglycoside, and third-generation cephalosporins. Data reviewed from Thailand’...

Cephalosporins have been well known to have potent convulsant activity. We studied the mechanism of the convulsions induced by cephalosporins. Cefazolin, cephaloridine, cefpirome and cefmetazole inhibited the receptor binding of gamma-aminobutyric acid (GABA), an inhibitory transmitter in the mammalian central nervous system. As fluoroquinolones also inhibited GABA receptor binding and this inh...

Cefuroxime sodium is a second-generation parentally administered cephalosporin, used in both human and veterinary medicine. In veterinary medicine, cefuroxime sodium, active on Streptococcus agalactiae, Streptococcus dysgalactiae, is administered intramammary for the treatment of mastitis in cattle during the lactating period. Cefquinome sulphate is a fifth generation cephalosporin, which is ad...

isolate was sent for confirmation and serotyping to National Salmonella and Escherichia reference centre, Kasuali, Himachal Pradesh, India. It was identified as S.typhimurim 4, 5 12:i:1,2. The isolate was sensitive to ciprofloxacin and norfloxacin with resistance to third generation cephalosporins, aminoglycosides, ampicillin, chloramphenicol and co-trimonazole. No Mycobacterium or fungus was i...

The World Health Organization Western Pacific Region Gonococcal Antimicrobial Surveillance Programme (WHO WPR GASP) examined approximately 8,400 isolates of Neisseria gonorrhoeae from 16 countries for resistance to relevant antibiotics in 2006. Antimicrobial resistance was at record levels in the region and poses major problems for the management of this important disease. High rates of resista...

We report three patients infected with unique strains of vancomycin-dependent enterococci. Two were first infected by genetically identical strains of vancomycin-resistant enterococci (VRE). All three patients had much greater exposure to vancomycin and third-generation cephalosporins than did two control groups (patients infected with VRE and hospitalized patients without enterococcal infectio...