In toxicology, it is often of interest to perform a Dunnett’s test to determine whether a pesticide or toxic substance is different at various levels from a control. The problem is complicated by the fact that often a traditional analysis of variance (ANOVA) model cannot be used because of a complex variance structure. For example, it might be of interest to determine whether rats receiving dif...

Based on the latest MLCS17 SNe Ia data provided by Hicken et al. (2009), together with the Baryon Acoustic Oscillation (BAO) and strong gravitational lenses (SGL), we investigate the dark energy equation-of-state parameter for both constant w and time-varying w(z) = w0 + waz/(1 + z) in the flat universe, and its correlation with the matter density ΩM and Hubble constant h. The constraints from ...

An important mobile health (mHealth) task is the use of multimodal data, such as sensor streams and self-report, to construct interpretable timeto-event predictions of, for example, lapse to alcohol or illicit drug use. Interpretability of the prediction model is important for acceptance and adoption by domain scientists, enabling model outputs and parameters to inform theory and guide interven...

The lme4 package uses sparse matrix technology and clever decompositions of the likelihood to fit linear, generalized, and nonlinear mixed-effects models. The amer package extends lme4’s scope to include generalized additive mixed models (GAMM). This vignette summarizes the main ideas behind additive models and their representation in the form of a mixed model, describes the modifications to lm...