Transcriptomes are known to organize themselves into gene co-expression clusters or modules where groups of genes display distinct patterns coordinated synchronous expression across independent biological samples. The functional significance these is suggested by the fact that highly coexpressed tend be enriched in involved common functions and processes. While widely assumed reflect close regu...

The reconstruction of many biological networks has allowed detailed studies of their structural properties. Several features exhibited by these networks have been interpreted to be the result of evolutionary dynamics. For instance the degree distributions may follow from a preferential attachment of new genes to older ones during evolution. Here we argue that even in the absence of any evolutio...

Genetic toggle switches are widespread in gene regulatory networks (GRN). Bistability, namely the ability to choose among two different stable states, is an essential feature of switching and memory devices. Cells have many regulatory circuits able to provide bistability that endow a cell with efficient and reliable switching between different physiological modes of operation. It is often assum...

Epithelial-to-Mesenchymal Transition (EMT) plays a key role in epithelial-cancer. The state trajectory of its underlying Gene Regulatory Network (GRN) includes three fixed-point attractors characterizing epithelial, senescent, and mesenchymal, cell phenotypes, which implies specific cell-to-cell cell-to-tissue interactions. interplay between the GRN driving EMT one regulating Mammalian Cell Cyc...

In this paper we investigate equilibria of continuous differential equation models network dynamics. The motivation comes from gene regulatory networks where each directed edge represents either...

With the rapid growth of wireless access networks, various providers offer their services using different technologies such as Wi-Fi, Wimax, 3G, 4G and so on. These networks compete for the scarce wireless spectrum. The spectrum is considered to be a scarce resource moderated by the spectrum allocation regulatory (“regulatory” for short) which is the governance body aiming to maximize the socia...