نتایج جستجو برای: gene inhibitors
تعداد نتایج: 1290958 فیلتر نتایج به سال:
Strawberry crown rot is a serious fungal disease that poses great threat to strawberry production in the growth cycle. The dominant pathogens of were different periods. main pathogen at seedling stage unclear. In this study, 74 Colletotrichum spp. isolated from 100 plants stage. Based on morphological observations and phylogenetic analysis multiple genes (ACT, CAL, CHS, GAPDH, ITS), all tested ...
Gene silencing by feeding double-stranded (dsRNA) holds promise as a novel pest management strategy. Nonetheless, degradation of dsRNA in the environment and within insect gut, well inefficient systemic delivery are major limitations to applying this Branched amphiphilic peptide capsules (BAPCs) complexed with have been used successfully target genes outside inside gut epithelium upon ingestion...
In previous studies, the heat shock response, induced by hyperthermia or sodium arsenite, increased interleukin (IL)-6 production in intestinal mucosa and cultured human enterocytes. A novel way to induce the heat shock response, documented in other cell types, is treatment with proteasome inhibitors. It is not known if proteasome inhibition induces heat shock in enterocytes or influences IL-6 ...
BACKGROUND & AIMS Cholangiocarcinomas (CCA) are resistant to chemotherapy, so new therapeutic agents are needed. We performed a screen to identify small-molecule compounds that are active against CCAs. Levels of microRNA 21 (MIR21 or miRNA21) are increased in CCAs. We investigated whether miRNA21 mediates resistance of CCA cells and organoids to HSP90 inhibitors. METHODS We performed a high-t...
Objective Fusions involving neurotrophic tyrosine receptor kinase ( NTRK ) are known oncogenic drivers in a broad range of tumor types. It recently gained attention as predictor targeted therapy since selective inhibitors now approved the US and Europe for patients with solid tumors harboring gene fusions. However, estimation fusion/alteration frequency its clinicopathological characteristics p...
Despite several new therapeutic options, multiple myeloma (MM) patients experience relapses and inevitably become refractory to treatment. Insights into drug resistance mechanisms may lead the development of novel treatment strategies. The S100 family is comprised 21 calcium binding protein members with 17 genes located in 1q21 region, which commonly amplified MM. Dysregulated expression associ...
Endothelial leukocyte adhesion molecule-1 (ELAM-1) is a membrane protein exclusively expressed on endothelial cells, where it plays a key role in the inflammatory response by adhering to a subset of leukocytes. The expression of the ELAM-1 gene is very tightly regulated. ELAM-1 is undetectable in uninduced cells, and it is transiently expressed following cytokine induction. Treatment of resting...
The regeneration of pancreatic islet beta cells is important for the prevention and cure of diabetes mellitus. We have demonstrated that the administration of poly(ADP-ribose) synthetase/polymerase (PARP) inhibitors such as nicotinamide to 90% depancreatized rats induces islet regeneration. From the regenerating islet-derived cDNA library, we have isolated Reg (regenerating gene) and demonstrat...
Fungal conidia contain chemicals that inhibit germination and appressorium formation until they are well dispersed in a favorable environment. Recently, such self-inhibitors were found to be present on the conidia of Magnaporthe grisea, and plant surface waxes were found to relieve this self-inhibition. To determine whether the self-inhibitors suppress the expression of early genes involved in ...
Abstract BACKGROUND Aberrant activity of the H3K27 modifiers EZH2 and BRD4 is an important oncogenic driver for atypical teratoid/rhabdoid tumor (AT/RT), each potentially a possible therapeutic target treating AT/RT. Thus, targeting distinct histone modifier activities would be effective approach METHODS The effects inhibition on modification, cell proliferation, invasion were analyzed by immun...
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