A new paradigm for an effective delivery of therapeutics into cancer cells is presented. Degradable porous silicon carriers, which are tailored to carry and release a model anti-cancer drug, are biolistically bombarded into in-vitro cancerous targets. We demonstrate the ability to launch these highly porous microparticles by a pneumatic capillary gene gun, which is conventionally used to delive...

This year, 2004, will see political realignments that will affect gun-owner rights for years to come. The current Bush administration has been a period of inertia in terms of advancing new controls, but this is largely due to the administration being distracted by the War on Terror. During his campaign for the presidency in 2000, Bush favored extending the “assault-weapons” ban of 1994 that sun...

Background Gun shows are an important source of firearms, but no adequately powered studies have examined whether they are associated with increases in firearm injuries. Objective To determine whether gun shows are associated with short-term increases in local firearm injuries and whether this association differs by the state in which the gun show is held. Design Quasi-experimental. Setti...

purpose: to report the first case of concomitant optic nerve transection and chorioretinitis sclopetaria patient and findings: a 12-year-old boy with history of bb gun injury to his right eye was referred for loss of vision 8 months after the accident. visual acuity in the right eye was counting fingers at one meter with 3+ rapd. on slit lamp examination, right eye seemed normal except 1+ anter...

We describe an innovative aspirator gun designed to transfer individual anesthetized mosquitoes directly into glass bioassay tubes. The gun has been used for thousands of transfers with extremely low associated mortality and is the central component of a high-throughput bioassay system. The gun is constructed using readily obtainable materials and can be modified for a range of insects.

PURPOSE Keratin 12 (K12) is a cornea epithelial cell-specific intermediate filament component. To provide a better understanding of its expression, it is necessary to identify and characterize the promoter of Krt1.12 gene. METHODS The 2.5-kb DNA 5' to Krt1.12 gene was sequenced. Krt1.12 promoter-beta-gal DNA constructs were prepared and used in vivo to transfect rabbit corneas, conjunctivas, ...

BACKGROUND An estimated 3700 individuals are seen annually in US emergency departments for nail gun-related injuries. Approximately 45 cases have been reported in the literature concerning nail gun injuries penetrating the cranium. These cases pose a challenge for the neurosurgeon because of the uniqueness of each case, the dynamics of high pressure nail gun injuries, and the surgical planning ...

OBJECTIVE School-associated firearm violence among children and adolescents is a national public concern. The objective of this study was to determine the accessibility of firearms, methods of firearm access and firearm safety knowledge among middle and high school students in Orange County, California. METHODS After permission from school officials and parents was obtained, a 24-question sur...

Gun violence is a major cause of preventable injury and death in the United States, leading to more than 33,000 deaths each year. However, gun violence prevention is an understudied and underfunded area of research. We review the barriers to research in the field, including restrictions on federal funding. We then outline potential areas in which further research could inform clinical practice,...

The Brookhaven Accelerator Test Facility (ATF) consists of a 50-MeV/c electron linac and a high-brightness RF-gun both operating at 2856 MHi. An extremely short (a few picoseconds) electron pulse with a low transverse emittance is generated by the RF-gun. In order to preserve both longitudinal and transverse emittances, great care must be taken in transporting the election beam from the RF-gun ...