Accurate segmentation of cervical nuclei is an essential step in the early diagnosis cancer. Still, there are few studies on clustered clusters cells. Because complexities high cell overlap, blurred boundaries, and cells, accurate remains a pressing challenge. In this paper, we purposefully propose GCP-Net deep learning network to handle challenging cluster images. The proposed U-Net-based cons...

Aspartoacylase (ASPA)-deficient patients [Canavan disease (CD)] reportedly have increased urinary excretion of N-acetylaspartylglutamate (NAAG), a neuropeptide abundant in the brain. Whether elevated excretion of urinary NAAG is due to ASPA deficiency, resulting in an abnormal level of brain NAAG, is examined using ASPA-deficient mouse brain. The level of NAAG in the knockout mouse brain was si...

Interleukin (IL) 1-ra is a potent endogenous competitive inhibitor of IL-α and β and has an anti-inflammatory role. Study objectives were: 1) to assess the associations of IL-1RN genetic single nucleotide polymorphism (SNP) (rs419598) with generalized chronic periodontitis (GCP), generalized aggressive periodontitis (GAgP), and absence of periodontitis and 2) to assess its association with the ...

Strain sensors with wide-range stretchability, good sensitivity, high gauge factor, and reliability are needed for several applications. Herein, stretchable strain capable of operating over multi-strain range having an excellent factor presented. The systematic study, carried out different combinations elastomer, conductive filler, graphene–carbon paste (GCP), revealed that the exhibit stretcha...

Recently, studies on the construction of 3D terrain modeling and location accuracy evaluation using UAV have been conducted, but application to coastal areas lacking image matching points has not made in detail yet. In topography survey UAV, ortho-images DSM (Digital Surface Model) data were constructed through imaging ground control point (GCP) surveying ground. case ortho-images, VRS was used...

Study specific training is an essential but often understated component of the study set up process for individual site personnel. One of the many challenges for the trial manager is to ensure study staff are appropriately trained without compromising rapid study start-up, quality of training, ethical compliance, GCP, running costs. A variety of training methods exist with different studies emp...

Following herpes simplex virus type 1 (HSV-1) ocular infection of C57BL/6 mice, activated CD8(+) T cells specific for an immunodominant epitope on HSV-1 glycoprotein B (gB-CD8 cells) establish a stable memory population in HSV-1 latently infected trigeminal ganglia (TG), whereas non-HSV-specific CD8(+) T cells are lost over time. The retention and activation of gB-CD8 cells appear to be influen...

Quality control, quality assurance, and audit are now an integral, though not always welcome, part of our daily lives. For many years the conduct of clinical trials has relied heavily on trust and the integrity of those involved, and the amount of regulation has been minimal. The introduction of the Declaration of Helsinki in 1964 spelt out the ethical considerations but further changes over th...

Cathodic protection is a corrosion management strategy for deteriorating reinforced concrete structures or it can be used as preventative measure in situations where may expected during the service life result of environmental exposure conditions. The technology has advanced over time. There are now number different systems that conveniently considered three categories, including impressed curr...