SIM-Lite is an astrometric interferometer being designed for sub-microarcsecond astrometry, with a wide range of applications from searches for Earth-analogs to determining the distribution of dark matter. SIM-Lite measurements can be limited by random and systematic errors, as well as astrophysical noise. In this paper we focus on instrument systematic errors and report results from SIM-Lite’s...

Using General Circulation Models (GCMs) for tropical cyclone studies is difficult due to the relatively small size of the storms, the intense convection and multitudes of large-scale small-scale interactions. These are mostly unresolved at typical GCM resolutions of about 50-100 km, and still challenged at high resolutions between 12-30 km. Nevertheless, high-resolution GCMs are becoming a tool...

The representation of cloud systems and cloud-radiation interaction is considered to be one of major uncertainties in general circulation models (GCMs). This arises because (1) complete observations of cloud systems are impossible and available measurements are very limited; (2) cloud-radiation interactions are scale-dependent (Dudek et al. 1996) while current GCMs cannot explicitly resolve the...

BACKGROUND Simvastatin increases the expression of bone morphogenetic protein 2 (BMP-2) in osteoblasts, therefore it is important to investigate the influence of statins on bone formation, fracture healing and implant integration. The aim of the present study was to investigate the effect of simvastatin, locally applied from intramedullary coated and bioactive implants, on bone integration usin...

Effects of green tea extract (GTE) on the activity of cytochrome P450 (CYP) enzymes and pharmacokinetics of simvastatin (SIM) were investigated in rats. Inhibitory effects of GTE on CYP3A activity were investigated in rat hepatic microsomes (RHM) using midazolam (MDZ) 1'-hydroxylation as a probe reaction. SD female rats received a single oral dose of GTE (400 mg/kg) or troleandomycin (TAO, a CY...

Mobile networks security is constantly evolving and adapting to meet the needs of users and network operators. It is a requirement that there be interoperation of legacy security frameworks into modern mobile networks. Mobile networks originally had no real security which proved to be a deployment that was attacked constantly and the providers were defrauded of millions of dollars. To address t...

The single-minded (sim) gene of Drosophila encodes a nuclear protein that plays a critical role in the development of the neurons, glia, and other nonneuronal cells that lie along the midline of the embryonic CNS. Using distinct cell fate markers, we observe that in sim mutant embryos the midline cells fail to differentiate properly into their mature CNS cell types and do not take their appropr...