نتایج جستجو برای: gata3 factors
تعداد نتایج: 1079192 فیلتر نتایج به سال:
ABSTRACT Notch signaling governs crucial aspects of intercellular communication spanning antigen-presenting cells and T-cells. In this study, we investigate how Leishmaniadonovani takes advantage pathway to quell host immune responses. We report induction the ligand Jagged1 in L. donovani-infected bone marrow macrophages (BMMϕs) subsequent activation RBPJκ (also known as RBPJ) T cells, which tu...
The differentiation of T helper cells into distinct functional subtypes is critical for mediating effective adaptive immune responses. The molecular mechanism by which a Th precursor cell (Thp) adopts a Th1 or Th2 phenotype involves a complex interplay between the induction of lineagespecific transcription factors, such as T-bet, Gata3, and c-Maf, and the stimulatory effects of the cytokine mil...
This study aimed to evaluate the diagnostic and prognostic roles of GATA-binding protein 3 (GATA3) immunohistochemistry in urothelial carcinoma (UC) using a meta-analysis. We investigated GATA3 immunohistochemical expression rates performed subgroup analysis based on tumor site, location, histological subtypes. The overall survival patients with GATA3-positive -negative UC were compared. estima...
Introduction The three groups of helper innate lymphoid cells (ILCs), namely ILC1, ILC2 and ILC3, have been identified by flow cytometry combinations cell surface markers. Here, we review various ways ILCs are currently identified, focusing on potential problems their solutions. first step to identify all is exclude other lymphocytes myeloid lineage-specific markers (Lin). However, the Lin cock...
The ELK3-GATA3 axis orchestrates invasion and metastasis of breast cancer cells in vitro and in vivo
Triple-negative breast cancer is a highly aggressive tumor subtype that lacks effective therapeutic targets. Here, we show that ELK3 is overexpressed in a subset of breast cancers, in particular basal-like and normal-like/claudin-low cell lines. Suppression of ELK3 in MDA-MB-231 cells led to transdifferentiation from an invasive mesenchymal phenotype to a non-invasive epithelial phenotype both ...
Th1 and Th2 cell fates are traditionally viewed as mutually exclusive, but recent work suggests that these lineages may be more plastic than previously thought. When isolating splenic CD4(+) T cells from mice infected with the parasitic helminth Schistosoma mansoni, we observed a defined population of IFN-γ/IL-4 double-positive cells. These IFN-γ(+) IL-4(+) cells showed differences in DNA methy...
The severity of most human birth defects is highly variable. Our ability to diagnose, treat and prevent defects relies on our understanding of this variability. Mutation of the transcription factor GATA3 in humans causes the highly variable hypoparathyroidism, sensorineural deafness and renal dysplasia (HDR) syndrome. Although named for a triad of defects, individuals with HDR can also exhibit ...
A recent comprehensive whole genome analysis of a large breast cancer cohort was used to link known and novel drivers and substitution signatures to the transcriptome of 266 cases. Here, we validate that subtype-specific aberrations show concordant expression changes for, for example, TP53, PIK3CA, PTEN, CCND1 and CDH1. We find that CCND3 expression levels do not correlate with amplification, w...
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