The E2A transcription factors are required for normal T lymphopoiesis and to prevent T lymphocyte progenitor transformation. Ectopic expression of E2A proteins in E2Adeficient lymphomas results in growth arrest and apoptosis indicating that these cells remain responsive to the targets of E2A. Here we identify the transcriptional repressor Growth factor independence (Gfi) 1b as a target of E2A t...

A key question in cancer systems biology is how to use molecular data to predict the biological behavior of tumors from individual patients. While genomics data have been heavily used, protein signaling data are more directly connected to biological phenotype and might predict cancer phenotypes such as invasion, metastasis, and patient survival. In this study, we mined publicly available data f...

Abstract Background Reduced endothelial Tie2 expression occurs in diverse experimental models of critical illness, and suppression is sufficient to increase spontaneous vascular permeability. Looking for a common denominator among different illnesses that could drive the same suppressive (thereby leak inducing) phenotype, we identified “circulatory shock” as shared feature postulated flow-depen...

In April 2011, leading stem cell researchers from all over the world came together for the 6th International Meeting of the Stem Cell Network North Rhine Westphalia (www .kongress.stammzellen.nrw.de), organized by Hans Schöler (Münster), Oliver Brüstle (Bonn), and Peter Horn (Essen). Notably, more than 600 participants, presenting 136 posters, joined the congress in Essen attracted by the scien...

In mouse embryos, segregation of the inner cell mass (ICM) and trophectoderm (TE) lineages is regulated by genes, such as OCT-4, CDX2 and TEAD4. However, the molecular mechanisms that regulate the segregation of the ICM and TE lineages in porcine embryos remain unknown. To obtain insights regarding the segregation of the ICM and TE lineages in porcine embryos, we examined the mRNA expression pa...