PURPOSE Gastrointestinal neuroendocrine carcinoma (NEC) is extremely aggressive, but its pathophysiologic features remain poorly understood. There have been no biologically specific markers for this disease. In this study, distinctive up-regulation of human achaete-scute homologue 1 (hASH1) in gastrointestinal NECs was clarified. EXPERIMENTAL DESIGN Expression of hASH1 in NECs (n=10), carcino...

Cyclooxygenase (COX), the key enzyme for synthesis of prostaglandins, exists in two isoforms (COX-1 and COX2). COX-1 is constitutively expressed in the gastrointestinal tract in large quantities and has been suggested to maintain mucosal integrity through continuous generation of prostaglandins. COX-2 is induced predominantly during inflammation. On this premise selective COX-2 inhibitors not a...

mucosa-adhesive gels can be used as a useful mean of delivering drugs to or via mucosal membranes, and in particular buccal mucosa. carbomers are among the best mucosa-adhesive materials known. the aim of this study was to compare the results obtained from the mucosa-adhesive strength of aqueous gels containing carbomers, either alone or in combination, to the data obtained from assessing the d...

Cyclooxygenase (COX), the key enzyme for synthesis of prostaglandins, exists in two isoforms (COX-1 and COX2). COX-1 is constitutively expressed in the gastrointestinal tract in large quantities and has been suggested to maintain mucosal integrity through continuous generation of prostaglandins. COX-2 is induced predominantly during inflammation. On this premise selective COX-2 inhibitors not a...

Cyclooxygenase (COX), the key enzyme for synthesis of prostaglandins, exists in two isoforms (COX-1 and COX2). COX-1 is constitutively expressed in the gastrointestinal tract in large quantities and has been suggested to maintain mucosal integrity through continuous generation of prostaglandins. COX-2 is induced predominantly during inflammation. On this premise selective COX-2 inhibitors not a...

today bleach and detergents are being frequently used and some people use their mixture for more cleaning. because of chemical interaction of bleach and detergent, chlorine gas was released and thereby it could be dangerous for human health. this study examined the effects of exposed toxic mixture of bleach and detergent on the mucosa layer and lamina mucosa conjunctiva in the mice. in this stu...

we report a rare case of congenital foregut cysts (esophageal bronchogenic cyst) in a young woman with history of long term dysphagia. she presented with dysphagia and upper gastrointestinal endoscopy showed bulge submucosal lesion in the distal of the esophagus. endoscopic ultrasound showed a 3×3 cm cystic lesion suggestive for esophageal duplication or bronchogenic cyst. computed tomography o...

INTRODUCTION Involvement of upper gastrointestinal tract in pemphigus vulgaris is not uncommon. AIM To study the involvement of upper gastrointestinal tract (UGIT) with the help of esophago-gastro-duodenoscopy (EGD) in patients of vesiculobullous dermatoses with emphasis on pemphigus vulgaris. METHODS Forty-two patients (M-22, F-20) with vesiculobullous dermatoses, diagnosed on the basis of...

Cyclooxygenase (COX), the key enzyme for synthesis of prostaglandins, exists in two isoforms (COX-1 and COX2). COX-1 is constitutively expressed in the gastrointestinal tract in large quantities and has been suggested to maintain mucosal integrity through continuous generation of prostaglandins. COX-2 is induced predominantly during inflammation. On this premise selective COX-2 inhibitors not a...