Heterocellular communication between vascular smooth muscle cells (VSMC) and endothelial cells (EC) at the myoendothelial junction (MEJ) is a critical part of control of the arteriolar wall. We have developed an in vitro model of the MEJ composed of primary cultures of murine EC and VSMC. Immunoctytochemistry and immunoblots demonstrated Cx37 and Cx43 in both cell types, whereas Cx40 was found ...

We describe a biasing scheme for single-photon detectors based on superconducting tunnel junctions. It replaces a single detector junction with a circuit of three junctions and achieves biasing of a detector junction at subgap currents without the use of an external magnetic field. The biasing occurs through the nonlinear interaction of the three junctions, which we demonstrate through numerica...

IN THE ABSENCE of functioning anomalous connection between atria and ventricles, the A-V junction serves as the only link between these structures, allowing the atrial impulse to be transmitted to the ventricles. The A-V junction may be defined as consisting of the atrial approaches to the A-V node, the A-V node itself, and the penetrating portion of the His bundle. Total transection of the A-V...

RATIONALE Posttranslational phosphorylation of connexin43 (Cx43) has been proposed as a key regulatory event in normal cardiac gap junction expression and pathological gap junction remodeling. Nonetheless, the role of Cx43 phosphorylation in the context of the intact organism is poorly understood. OBJECTIVE To establish whether specific Cx43 phosphorylation events influence gap junction expre...

Abstract—This paper presents the design parameters for a thin film 3J InGaP/GaAs/Ge solar cell with a simulated maximum efficiency of 32.11% using Tcad Silvaco. Design parameters include the doping concentration, molar fraction, layers’ thickness and tunnel junction characteristics. An initial dual junction InGaP/GaAs model of a previous published heterojunction cell was simulated in Tcad Silva...

The spontaneous flux generation and magnetic field modulation of the critical current in a 0−π Josephson junction are calculated for different ratios of the junction length L to the Josephsen penetration depth λJ , and different ratios of the 0-junction length to the π-junction length. These calculations apply to a Pb-YBCO c-axis oriented junction with one YBCO twin boundary, as well as other e...

A realization of a reflectionless power splitter is proposed by use of a metamaterial junction. To design the junction, the electromagnetic wave transmission in multiple connected leads is investigated theoretically and numerically. A closed analytical form is derived for the scattering matrix of any geometry of the interconnected leads. We show that the use of a junction made of ϵ-near-zero (E...

*Correspondence: Graham T. Reed, Optoelectronic Research Centre, University of Southampton, Mountbatten Building, Highfield, Southampton, Hampshire SO17 1BJ, UK e-mail: [email protected] This paper presents new experimental data from a lateral PN junction silicon Mach-Zehnder optical modulator. Efficiencies in the 1.4 to 1.9 V/cm range are demonstrated for drive voltages between 0 V and 6 V. H...

Molecular electronics aims to construct functional molecular devices at the single-molecule scale. One of the major challenges is to construct a single-molecule junction and to further manipulate the charge transport through the molecular junction. Break junction techniques, including STM break junctions and mechanically controllable break junctions are considered as testbed to investigate and ...

A method is described that uses trypsin digestion combined with collagenase-hyaluronidase which produces a population of gap junction vesicles. The hexagonal lattice of subunits ("connexons") comprising the gapjunctions appears unaltered by various structural criteria and by buoyant density measurements. The gap junction vesciles are closed by either a single or a double profile of nonjunctiona...