A 26-year-old woman was regularly followed up in a gastro-intestinal out-patient clinic. Since early childhood, she was noted to have hyperpigmented lesions over the perioral region (Fig 1a) and fingers (Fig 1b), and a history of small intestinal intussusception due to polyps that was treated by surgery when she was 12 years old. Endoscopic assessment revealed multiple gastric polyps (Fig 1c) a...

Over several centuries, oral dosage forms have remained incomparably superior to alternative medication delivery methods. For its ease of formulation and administration, stability, excellent rate patient compliance, the route is preferred. Gastric emptying has been a major drawback for drugs that stay very short period in stomach. An innovative method gastro-intestinal retention allows form gas...

To date, most concepts on the frequency of gastro-oesophageal reflux episodes and the efficiency of the antireflux barrier have been based on inferences derived from measurement of oesophageal pH. The development of intraluminal impedance monitoring has highlighted the fact that pH monitoring does not detect all gastro-oesophageal reflux events when little or no acid is present in the refluxate...

M.D. (Pp. xii + 566; figs. 415. 144s.) London: Bailliere, Tindall & Cox, 1958. THIS work covers every conceivable aspect of obstruction in the gastro-intestinal tract from the cesophagus to the anal canal in a truly encycloprdic manner. The book contains a tremendous amount of information and approximately 1,700 references in the bibliography. It is refreshing here to note that the authors incl...

Professor of Greek tells me that he truly believes the classics have made him what he is. This is a very grave statement, if well founded. Indeed, I have heard the same argument from a great many Latin and Greek scholars. They all claim, with some heat, that Latin and Greek have practically made them what they are. This damaging charge against the classics should not be too readily accepted. In...

Gastro-esophageal reflux (GER) is a physiological phenomenon occurring in every individual. Gastro-esophageal reflux Disease (GERD) is a pathological condition where the reflux into the esophagus causes local changes and aspiration of the gastric contents in to the lungs can cause serious, even life threatening conditions. GERD is common but under-diagnosed condition in children. There are fund...

CHAIRMAN. Have you any idea of the success rate of diagnosis of carcinoma of the pancreas. Are there any false positives? HERLINGER. I haven't attempted to prove any diagnostic abilities but I was quite happy to go back after I had been proved wrong, to see whether I could have been right if I had known more, and making use of this retrospective diagnosis I would say that the correlation betwee...

Gastro-esophageal reflux (GER) is common in infants and children and has a varied clinical presentation: from infants with innocent regurgitation to infants and children with severe esophageal and extra-esophageal complications that define pathological gastro-esophageal reflux disease (GERD). Although the pathophysiology is similar to that of adults, symptoms of GERD in infants and children are...

In adults, most intussusceptions develop from a lesion, usually a benign or malignant neoplasm, and can occur at any site in the gastrointestinal tract. Intussusception in the proximal gastrointestinal tract is uncommon, and gastro-gastric intussusception is extremely rare. We present a case of gastro-gastric intussusception secondary to a primary gastric lymphoma. An 82-year-old female patient...

Sandifer syndrome (SS), a movement disorder which is characterised by spasmodic torsional dystonia with back arching and rigid opisthotonic posturing, negatively impacting predominantly the neck, back, upper extremities. Symptomatic gastro-esophageal reflux disease, esophagitis, or presence of hiatal hernia are all associated syndrome. The cause being uncertain, lifestyle adjustments modificati...