Glycyrrhiza glabra L. is used in folk medicine for treatment of stomach disorders including peptic ulcers. The hydroalcoholic extract of Glycyrrhiza glabra L. (HEGG) was evaluated for antiulcerogenic activity and acute toxicity profile in mice. Various doses of HEGG (50-200 mg/kg) were administered orally to animals of different groups. Omeprazole and cimetidine at doses of 30 and 100 mg/kg wer...

Background: Escin was a natural mixture of triterpenoid saponin that was isolated from the seed of the horse chestnut. The previous study from our laboratory demonstrated that escin had a protective effect against indomethacin-induced gastric ulcers in mice. The aim of this study was to investigate the effect of escin on gastric mucosal lesions induced by water immersion and restraint stress (W...

background: to asses the status of two representative genes of cag pai i.e caga and cage of helicobacter pylori strains infecting iranian patients suffered from various clinical outcomes using one-step pcr. methods: a total of 120 h. pylori infected patients including non-ulcer dyspepsia, nud (n=81), peptic ulcer disease, pud (n=17), and gastric carcinoma, gc (n= 22) referred for endoscopy or g...

BACKGROUND Gastric peptic ulcer is one of the common disorders of gastrointestinal tract, which occur due to an imbalance between the offensive and defensive factors. It is an illness that affects a considerable number of people worldwide. This study was conducted to evaluate the antiulcerogenic and antiulcer effects and recognize the basic mechanism of action of Piptadeniastrum africanum stem ...

It has been reported that many anti-inflammatory drugs employed in the treatment of rheumatic disorders cause various gastrointestinal disturbances , such as haemorrhage and the development or reactivation of peptic ulcer . The mechanisms involved are not understood precisely, but they may include stimulation of gastric acid secretion and de crease in the resistance of the local gastrointestina...

Introduction: One of the most prevalent gastrointestinal ailments is gastric ulcer, which caused by an imbalance between protective and aggressive factors. Zea mays Corn a significant cereal crop containing natural phytochemical substances that are sources nourishment. The methanolic extract Corn, according to previous study, lowers stomach acidity inhibits percentage ulceration with no knowled...

Melatonin is known as a potent scavenger of reactive oxygen species. Zinc has also been reported to be involved in tissue regeneration. This activity has been suggested partly as its gastroprotective mechanism. The digestive system has been estimated to produce about 400 times of this neurohormone than the pineal gland. In this study, we report the role of gastric anti-oxidant enzymes, luminal ...

The inhibitory effect of indomethacin, 200 + 200 mg administered per os over 24 hours, on the prostaglandin E2 generative capacity of gastric mucosal tissue was determined in healthy male volunteers. The effect of prostaglandin synthesis inhibition on somatostatin induced suppression of food-stimulated acid secretion was tested. Peptone meal stimulated acid secretion was quantified in five heal...